Human Brain Proteome Project
Overview of Project
The brain is the most complex organ of higher organisms, differing from other organs due to its many different cell types, its structure at the cellular and tissue level. At the same time, the brain is of highest paramount interest in medical research and pharmaceutical industry because of the widespread public caused by the more common neurological diseases such as Alzheimer‘s Disease and Parkinson‘s Disease.
Therefore, one aim of the HUPO Brain Proteome Project is the characterization of the human and mouse brain proteomes and the use of the gainedutility of this data (identified proteins, mRNA profiles, protein/protein interactions, protein modifications and localization, validated targets) to compare in comparison to mouse models of human disease and to relevant human tissue-autopsy materials for human neurodegenerative diseases. In order to reach this goal, it is necessary to coordinate the neuroproteomic activities worldwide and to enable every participant and active member of the HUPO BPP to access all data and new technologies obtained through these studies.
After the first phase of especially technological evaluations and establishment of SOPs for proteome analysis of the brain as well as body fluids we have now entered the next phase of the project aiming to:
- understand neurodegenerative diseases and aging.
- identify prognostic and diagnostic biomarkers.
- push new diagnostic approaches and medications.
- define needs and guidelines for proteomic approaches in brain research.
- exchange knowledge with other HUPO projects and national/international projects.
Collaborations with other Initiatives
Strong collaborative relationships are in place with:
- HUPO Proteomic Standards Initiative (PSI) - for bioinformatics and standardization efforts
- HUPO Liver Proteome Project - via governmental Chinese-German Cooperation
- HUPO Plasma Proteome Project
Key Documents Related to Activities
- 2010 Report to the HUPO Council from the Brain Proteome Initiative
- Sep 27, 2009 Report to HUPO Board of Directors
- Previous HUPO BPP Workshops
- SOPs and Guidelines
- Special Issue Proteomics 2006 “HUPO HBPP”
Future meetings with dedicated sessions
Spring HUPO BPP Workshop 2010, Korea:
The workshop will be held in Ochang (near Chungju) from March 30th-31st (1 ½ days)
- Beginning: March 30th, 9 a.m.; end: March 31st, 12 a.m. After lunch there will be transfer to Seoul for the participants of the KHUPO meeting.
- speakers: already fixed are Lea Grinberg, Jens Wiltfang, Helmut E. Meyer, Young Mok Park, Katrin Marcus, Harry Steinbusch (Maastricht) and Isabelle Fournier (Univ Lille).
Autumn HUPO BPP Workshop 2010, Sydney:
- A special topic/focus will be defined within the next three months. It will be technology based, e.g. membrane proteomics, challenges in proteome analysis of brain samples, accessibility and quality of human samples. Speakers are to be named soon.
Spring HUPO BPP Workshop 2011:
- Suggested place: Bonn, DZNE
Date: close to the Proteomic Forum 2011 (March/April 2011)
General points:The idea has come up that spring workshops should be clinical oriented, autumn workshops (during the HUPO meetings) should be more technology/proteomics oriented in order to attract more attendees. Clinicians should be integrated, especially in the spring workshops. Also, companies should be contacted.