Human Proteome Project (HPP)
HUPO announced the global Human Proteome Project (HPP) at the Sydney World Congress in September 2010 and launched the HPP at the Geneva World Congress in September 2011. The goal of the HPP is to identify and characterize at least one protein product from each of the 20,300 protein-coding genes. The timing reflects dramatic advances in the resource pillars for the HPP --a wide array of of mass spectrometry platforms, the antibody-based Human Protein; and ProteomeXchange to integrate proteomics-based knowledge-bases.
The HPP is organized into two investigative arms: a chromoome-centric HPP, with consortia so far, and a complementary effort to facilitate extensive biology and disease driven (B/D) proteomics projects. Progress will be illustrated with findings from the breast-cancer-driven Chromosome 17 project.
The HPP is governed by an Executive Committee and Senior Scientific Advisory Board.
Learn more - Go to the HPP website.
HPP Executive Committee
- Gil Omenn (USA) - Chair
- Ruedi Aebersold (Switzerland)
- Amos Bairoch (Switzerland)
- Fuchu He (China)
- Young-Ki Paik (Korea)
- Bill Hancock (USA) - Co-Chair, ex-officio from HUPO EC
- Micheal Snyder (USA) - Co-Chair, ex-officio from SSAB
- Pierre Legrain (France) - ex-officio HUPO President
HPP Senior Scientific Advisory Board
- Michael Snyder (USA) - Chair
- Cathy Costello (USA)
- Kunliang Guan (China)
- Denis Hochstrasser (Switzerland)
- Lee Hood (USA)
- Matthias Mann (Germany)
- Kate Rosenbloom (USA)
- Naoyuki Taniguchi (Japan)
- Mathias Uhlen (Sweden)
- John Yates (USA)
News and Key Documents
- Progress and Opportunities in the Human Proteome Project -a poster presented by Gil Omenn at the US HUPO 8th Annual Conference (March 4-7, 2012)
- Busan HPP Meetings March 30, 2011 - Download slides
- The call of the human proteome - Nature Methods 7, 661-661 (September 2010) doi:10.1038/nmeth0910-661 Editorial
- Mass spectrometry in high-throughput proteomics: ready for the big time Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates, Amos Bairoch, John J M Bergeron Nature Methods 7, 681-685 (September 2010) doi:10.1038/nmeth0910-681 Commentary
- Report from the Second Meeting May 10 2010
- Rabilloud, T., Hochstrasser, D. and Simpson, R. J. (2010), Is a gene-centric human proteome project the best way for proteomics to serve biology?. PROTEOMICS, 10: 3067–3072. doi: 10.1002/pmic.201000220
- HUPO Views (Feb 2010): "A Gene Centric Human Proteome Project" Mol Cell Proteomics 9 (2): 427
- Report from the Kick Off Meeting January 2010
- Building the 'practical' human proteome project - the next big thing in basic and clinical proteomics. Curr Opin Mol Ther. 2009 Dec;11(6):600-2
- Proteomonitor - Human Proteome Project Revisited at HUPO; Methodology, Funding, Data Management Still Open Questions - Sept 28, 2009
- Human Proteome Project White Paper The "white paper" on the Human Proteome Project was written in August 2008. It was inspired by intense discussions during the 4th international Barbados Proteomics Conference that took place in January 2008. This paper was one of the major sources of inspiration of the HUPO Views article (MCP, Feb 2010).
- JPR - HUPO’s Human Proteome Project: the next big thing? – May 6, 2008
- Nature - Biologists initiate plan to map human proteome –Nature Vol 452 24 April 2008
HUPO Test Sample Related Papers
- (May 17, 2009) Press Release: HUPO has now published (Nature Methods) the results of a
three-year quality control study.
<read the press release>
- Nature Methods - A HUPO test sample study reveals common problems in mass spectrometry–based proteomics Nature Methods 6, 423 - 430 (2009)
- Nature Methods - a stress test for mass spectrometry–based proteomics - nature methods | VOL.6 NO.6 | JUNE 2009
Nature Methods - Comparative analysis to guide quality improvements in proteomics - nature methods | VOL.6 NO.10 | OCTOBER 2009
HPP Events
Upcoming Events
Past Events
- Busan, South Korea - March 30 2011
- HUPO 9th Annual World Congress, Sydney 2010
- HPP Canadian National Proteomics Network's (CNPN) brain storming session, Montreal - January 17, 2010
- CNPN /canadian Funding Agencies meeting, Montreal - January 18, 2010
- HPP Working Group Kickoff Meeting, Seattle - January 25, 2010
- European Scientific Foundation (ESF) HPP scoping meeting - February 26, 2010
- HPP Working Group second meeting, Montreal - May 10, 2010 -
- Canadian HPP workshop, Montréal, May 11, 2010
