The Human Glycoproteomics Initiative (HGI) purpose is to define community standards for data presentation in functional glycomics and glycoproteomics in relation to diseases. The goal is to facilitate data comparison, exchange and verification. The HGI will be comprised of a number of researchers and collaborators throughout the world who are dedicated to fostering and accelerating research progress in disease glycomics by pursuing collaborative and interdisciplinary research. This project will connect the other HPP activity in HUPO more tightly and will permit the exchange of information of mutual interest. The data and information will be shared with members, non-participating researchers and will be made available for public, academic research and teaching purposes. In order to avoid diluting efforts by other on-going related activities such as NIH consortium for functional glycomics, Japanese consortium for glycobiology and glycotechnology, Eurocarb etc, this initiative will focus exclusively on disease glycomics and glycoproteomics.

Current lines of work:

• Three pilot studies were performed in this HGI thus far and the results of the third pilot study were published in 2016. The next work is now under discussion. 

Links:

Papers:

1. Comparison of analytical methods for profiling N- and O-linked glycans from cultured cell lines : HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.

Ito H, Kaji H, Togayachi A, Azadi P, Ishihara M, Geyer R, Galuska C, Geyer H, Kakehi K, Kinoshita M, Karlsson NG, Jin C, Kato K, Yagi H, Kondo S, Kawasaki N, Hashii N, Kolarich D, Stavenhagen K, Packer NH, Thaysen-Andersen M, Nakano M, Taniguchi N, Kurimoto A, Wada Y, Tajiri M, Yang P, Cao W, Li H, Rudd PM, Narimatsu H.

Glycoconj J. 2016 Jun;33(3):405-15. doi: 10.1007/s10719-015-9625-3. Epub 2015 Oct 28.

PMID: 26511985

2. Comparison of methods for profiling O-glycosylation: Human Proteome Organisation Human Disease Glycomics/Proteome Initiative multi-institutional study of IgA1.

Wada Y, Dell A, Haslam SM, Tissot B, Canis K, Azadi P, Bäckström M, Costello CE, Hansson GC, Hiki Y, Ishihara M, Ito H, Kakehi K, Karlsson N, Hayes CE, Kato K, Kawasaki N, Khoo KH, Kobayashi K, Kolarich D, Kondo A, Lebrilla C, Nakano M, Narimatsu H, Novak J, Novotny MV, Ohno E, Packer NH, Palaima E, Renfrow MB, Tajiri M, Thomsson KA, Yagi H, Yu SY, Taniguchi N.

Mol Cell Proteomics. 2010 Apr;9(4):719-27. doi: 10.1074/mcp.M900450-MCP200. Epub 2009 Dec 28.

PMID: 20038609

3. Comparison of the methods for profiling glycoprotein glycans--HUPO Human Disease Glycomics/Proteome Initiative multi-institutional study.

Wada Y, Azadi P, Costello CE, Dell A, Dwek RA, Geyer H, Geyer R, Kakehi K, Karlsson NG, Kato K, Kawasaki N, Khoo KH, Kim S, Kondo A, Lattova E, Mechref Y, Miyoshi E, Nakamura K, Narimatsu H, Novotny MV, Packer NH, Perreault H, Peter-Katalinic J, Pohlentz G, Reinhold VN, Rudd PM, Suzuki A, Taniguchi N.

Glycobiology. 2007 Apr;17(4):411-22. Epub 2007 Jan 12. Erratum in: Glycobiology. 2007 May;17(5):10G.

PMID: 17223647

Leadership:

Nicki Packer, Chair