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Newsletter of the Human Proteome Organization

Current and past HUPOSTs are posted here for your review. Stories, highlights, news, and announcements are gladly accepted for inclusion in the HUPOST. Please submit your information to the HUPO Office at


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  • 05 Jan 2018 10:36 AM | Anonymous member (Administrator)

    Michelle Hill, QIMR Berghofer Medical Research Institute, and The University of Queensland, Australia

    On a beautiful sunny November day in Sydney, Australian proteomics practitioners had a first date with pathologists, at The RCPA Introduction to Proteomics in Pathology Course. The one-day course was co-organised by The Royal College of Pathologists of Australasia (RCPA) and The Human Proteome Organisation (HUPO), and included 17 invited lectures.

    The 59 delegates from pathology services, industry, universities and research institutes across Australia crowded The RCPA Professor Alan BP Ng Education Centre in Sydney. Following opening remarks by Associate Professor Peter Stewart (RCPA, organising committee), Professor Mark Baker outlined the Human Proteome Project, and Professor Marc Wilkins gave a lecture on the Principles of Proteomic Methodologies. Perhaps not unexpected, the cancer proteomics was featured in several lectures, including applications in cancer diagnostics (Associate Professor Rosemary Balleine), treatment decisions (Professor Roger Reddell), ProCan Program (Dr Peter Hains), as well as approaches to biomarker discovery (Professor Peter Hoffmann, Associate Professor Michelle Hill, Dr Charlie Ahn). Other topics included Quality Assured Big Data in Pathology (Associate Professor Tony Badrick), Bioinformatics Data Analysis (Professor Terry Speed), Pediome (Associate Professor Vera Ignjatovic), Microbiome (Dr Adam Rainczuk), Cardiovascular Disease (Dr Melanie White), and Personalised Medicine (Professor Ed Nice). The day concluded with panel discussion and drinks mixer.

    The enthusiasm was palpable, with the day being literally the first introduction to proteomics for most of the RCPA members attending the course. Robust discussions ensued on the analytical methods and quality assurance aspects of proteomic technologies, in comparison to pathology standards. With delegates showing a strong interest in marrying proteomics with pathology, it will not be surprising to see some second dates and success stories in the near future. Indeed, the upcoming Australian Association of Clinical Biochemists (AACB) joint Course ‘Assessing the Value of Biomarkers’ with European Federation of Clinical Chemistry and Laboratory Medicine is a timely follow-up opportunity to foster the relationship between proteomic biomarker researchers and clinical implementation.

    A personal highlight for me was meeting some of the (satisfied) clinicians who have submitted samples to the Princess Alexandra Hospital Amyloidosis Centre ( for proteomic typing of amyloidosis. While we recently published the results of our 5-year study (, it is not often that the scientists come face to face with end-users. At the end of a stimulating day, I head home on the late flight with renewed purpose and optimism for clinical applications of proteomics.

    PHOTO credit, The Royal College of Pathologists of Australasia (RCPA). Organizing committee for The Introduction to Proteomics in Pathology Course. From left to right, Prof Mark Baker (HUPO), A/Prof Peter Stewart (RCPA), Prof Rita Horvath (RCPA), Prof Ed Nice (HUPO). 

  • 05 Jan 2018 10:28 AM | Anonymous member (Administrator)

    In cooperation with B/D-HPP investigators, the C-HPP Special Issue JPR came out on December 1, 2017, which marks the fifth consecutive edition since the first issue has been published in January 2013. This issue culminates in total 191 papers which are focused on C-HPP initiative and related HPP topics. In this issue, 27 papers address (1) the accurate mapping of human protein parts list, which has been well progressed towards the completion of HPP goals and (2) advances in the proteomic technologies for the broader community (Paik et al., 2017, in Editorial). Those 27 manuscripts are categorized in four subjects: (i) Metrics of Progress and Resources, (ii) Missing Protein Detection and Validation, (iii) Analytical Methods and Quality Assessment, and (iv) Protein Functions and Disease.

    All manuscripts in JPR special issue provided data on missing proteins and other claims for new protein sequences in accordance with the Human Proteome Project Data Interpretation Guidelines (Version 2.1.0 - July 28, 2016) which requires mandatory full submission of LC-MS/MS data to ProteomeXchange. For this special issue the version of neXtProt issued on January 23, 2017 was used, which has confident protein identification for 17 008 human protein coding genes (category PE1) leaving 2 579 human protein coding genes for which evidence at protein levels should be found either using mass spectrometry or other analytical methods (missing proteins with protein evidence level PE2+PE3+PE4) and 572 human genes which are considered to be dubious (protein evidence PE5). Notably, authors report 73 new missing protein detections by mass spectrometry using several approaches. This data is currently being processed by PeptideAtlas and neXtProt and will be available in the next versions of these two resources, expected in January and February 2018, respectively. The 2018 special issue will be continued and was announced with a ‘Call for Papers’ in JPR, with deadline to submit manuscripts of May 31, 2018. This issue will also cover both C-HPP and B/D-HPP subjects. For this special issue the version of neXtProt that will be issued on February will serve as a reference. Read the December 2017 issue of the Journal of Proteome Research here.

  • 30 Nov 2017 2:03 PM | Anonymous member (Administrator)

    Lennart Martens HUPOST Editor, Ghent University, Belgium

    The focal point of 2017 was undoubtedly the HUPO 2017 World Congress in Dublin, which has been expertly captured in the short and snappy Congress Overview Video, which you can find on YouTube. Don't miss the very worthwhile cameos at the end!

    And while on the topic of must-see videos, make sure you've viewed the inspiring Welcome Address and thoroughly moving Keynote Speech by 47th Vice President of the United States Joseph R. Biden Jr. at the HUPO 2017 Leadership Gala in Dublin (both available on the HUPO home page).

    I would also like to take the opportunity to congratulate and welcome on board the newly elected HUPO Council Members, and of course HUPO  President-Elect Stephen Pennington.

    As promised, we have continued to evolve HUPOST over the course of 2017, which is now offered through an easily browsable overview so you can find your topics of interest even more quickly. I'm also very happy to announce that contributions from the various HUPO Initiatives will now be included in HUPOST as well, further broadening our content, and helping you to stay up-to-date with all that's happening in HUPO. And don't forget that you can always let us know at when youhave something to share, and that you can find us on social media: Facebook, Twitter, and LinkedIn.

    Finally, allow me to remind you that, if your HUPO membership is up for renewal, you can easily renew online through the HUPO website. Special rates apply for students and post-docs, while everyone else can take advantage of the discounted 3-year membership formula.

    Happy holidays and best wishes for the new year!

    Cheers, Lennart Martens 

  • 20 Nov 2017 5:42 AM | Anonymous member (Administrator)

    Michelle Hill, QIMR Berghofer Medical Research Institute, and The University of Queensland, Australia

    A new initiative at HUPO2017 was a round table discussion with clinical scientist travel grant winners, the B/D-HPP executives, selected previous clinical scientist travel grant winners, and HUPO2018 organiser Ileana Cristea. The goal of the round table discussion is to gain insight on the challenging facing clinical scientists in proteomics research, and feedback how HUPO could facilitate their clinical proteomics research. In addition, it was hoped that each of the travel grant winners could work closely within one or more B/D-HPP initiatives.

    The five award winners hail from across the globe, with broad specialities.

    Dr Mariette Labots is a medical oncologist at the VU University Medical Centre, Amsterdam, The Netherlands. She is currently pursuing PhD in the OncoProteomics Laboratory led by Dr Connie Jimenez. Dr Labots has worked on phosphoproteomics of cancer tissues in response to targeted therapies.

    Dr J Robert O’Neill is a clinical lecturer and honorary specialty registrat in upper gastrointestinal surgery, University of Edinburgh, UK. After completing his PhD in 2014, which involved the use of proteomics to explore therapeutic target discovery, Dr O’Neill is currently building a program in esophageal cancer research in Edinburgh.

    Dr Emma Nimeus is a breast cancer surgeon at Skane’s University Hospital and principal investigator for the Breast Cancer Proteogenomics Group at Lund University in Sweden, in the next-door buildilng. Dr Nimeus has established an interdisciplinary and international collaboration to enable proteogenomics research using clinical samples procured from her clinical practice.

    Professor Richard D. Semba is an ophthalmologist from Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. He is one of the leaders of B/D-HPP EyeOME initiative which began in 2012. Prof Semba’s research aims to understand three important blinding eye diseases: age-related macular degeneration, chronic angle closure glaucoma, and idiopathic macular holes.

    Dr Krishna R Murthy is a vitreo-retinal surgeon and the medical director of Vittala International Institute of Ophthalmology, Bangalore, India. He recently defended his PhD from Amrita Vishwa Vidyapeetham. Dr Murthy’s areas of clinical interest include diabetic retinopathy, Retinopathy of prematurity, HIV related eye diseases and proteomics of the ocular structures.

    The round table began with self-introductions of research areas, how proteomics technologies are accessed, and any challenges currently facing the travel award winners. In-depth discussions between the participants explored diverse topics including the need for proteomic (and lipidomic) research, challenges to obtain access to advanced mass spectrometry technologies and to keep abreast of the fast pace of technology change.

    Finally, B/D-HPP executives and HUPO2018 organisers solicited and received feedback on how the HUPO World Congress program could be modified to further facilitate clinical proteomics research and collaboration. Look out for new ideas and formats at HUPO2018!

    From left to right: Hui Zhang (Cancer HPP co-chair), Mariette Labots (grant winner), Ferdinando Cerciello (past grant winner, B/D-HPP ECR rep), Robert O’Neill (grant winner), Emma Nimeus (grant winner), Jenny Van Eyk (B/D-HPP chair and executive committee member), Richard Semba (grant winner), David Herrington (past grant winner), Murthy Krishna (grant winner), Eric Deutsche (B/D-HPP executive committee member). Not pictured: Gil Omenn (B/D-HPP ex-officio), Fernando Corrales (B/D-HPP co-chair), Ileana Cristea (HUPO2018 organiser), Michelle Hill (B/D-HPP news article editor).

  • 23 Oct 2017 5:45 AM | Anonymous member (Administrator)

    Nicki Packer, Macquarie University, Australia

    Protein glycosylation is a common and diverse modification crucial to the understanding of protein function in just about every biological system. Advances in mass spectrometry now allow hundreds and even thousands of unique intact glycopeptides to be identified from a single LC-MS/MS-based glycoproteomics experiment [1]. However, confident identification of intact glycopeptides is still challenging and correct spectral annotation remain heavily dependent on laborious manual expert interpretation of fragment mass spectra. Glycoproteomics is experiencing increasing attention these years not least within the HUPO community as demonstrated with a dedicated glycoproteomics sessions at HUPO2016. However, the described technical limitations are inhibiting new scientists from entering this exciting area of proteomics. Thus, there is a clear need for tools for accurate and confident automated glycopeptide identification.

    The past decade has seen promising developments of a range of MS-based software for intact glycopeptide identification [2]. To enable community evaluation of these developing tools, the new chair of the HGI, Prof Nicki Packer, Macquarie University, Sydney launched a new HGI study at HUPO2017. For this purpose, two large data files containing high resolution tandem mass spectral data of intact glycopeptides from human serum have been generated for this purpose by ThermoFisher. Combinations of dissociation modes (HCD, EThcD, ETciD and CID) were used to obtain the spectra. An expert panel will curate/analyse the data to create a consensus glycopeptide library, for comparison against the list of identifications being reported by participants in the study.

    We are calling for participants (of academic and/or industrial origin) that are either developers of glycoproteomics software and/or expert users (researchers) in glycoproteomics, to identify and report on the characterization of the intact serum glycopeptides using either their own software (developers) or by using one or more tools which they routinely use in their glycoproteomics research including manual interpretation (expert users). Participants are asked to report how they interpreted the data. We plan to send out the intact glycopeptide MS/MS data this year in order to present the preliminary results of the comparative study at the next HUPO in 2018, with a planned publication of the final results and conclusions to follow. Please contact if you would like to be part of this study.

    HGI Committee members:

    Prof Nicki Packer (Macquarie University and Griffith University, Australia) (Chair)

    Dr Morten Thaysen-Andersen, Macquarie University, Australia (Deputy Chair)

    A/Prof Daniel Kolarich, Griffith University, Australia (Deputy Chair)

    Dr Stuart Haslam, Imperial College, UK

    Prof Kai-Hooi Khoo, Academia Sinica, Taiwan

    Prof Goran Larson, Gothenburg University, Sweden

    Prof Katalin Medzihradszky, UCSF, USA

    Prof Giuseppe Palmisano, University of Sao Paulo, Brazil

    Prof Jong Shin Yoo, Korea Basic Science Institute, Korea

    Prof Joe Zaia, Boston University, USA


    [1] Thaysen-Andersen M, Packer NH, Schulz BL. Maturing Glycoproteomics Technologies Provide Unique Structural Insights into the N-glycoproteome and Its Regulation in Health and Disease. Mol Cell Proteomics. 2016. 15(6):1773.

    [2] Hu H, Khatri K, Klein J, Leymarie N, Zaia J. A review of methods for interpretation of glycopeptide tandem mass spectral data. Glycoconj J. 2016. 33(3):285.

    Design of the new HGI study to compare the performance of current glycoproteomics software for N- and O-glycopeptide identification from high resolution MS/MS spectral data of a complex mixture of serum proteins.

  • 25 Jul 2017 3:11 PM | Anonymous member (Administrator)

    Michelle Hill, QIMR Berghofer Medical Research Institute, and The University of Queensland, Australia

    Through the leadership of HUPO and Chromosome-centric HPP over the past several years, we now have a relatively complete ‘Parts List’ of the human proteome. The B/D-HPP initiatives spearheaded the characterization of tissue-specific proteomes in health and disease conditions, with most studies on adult-derived samples, and model organisations. The HPP-PediOme has a clear focus on the proteomic analyses of pediatric samples, including newborns, infants, young children and adolescents.  

    In addition to providing biomarkers for diagnosis of pediatric-specific conditions, pediatric proteome studies can also reveal early disease mechanisms for common adult conditions such as diabetes and obesity, thus contributing to prevention of disease. While proteomics analyses of pediatric samples present some obvious challenges, such as difficulty of sample collection and the limited sample volume compared to adult samples, the reduced number of potential confounding conditions may simplify the biomarker study design and analyses. 

    The human pediatric proteome (PediOme) project aims to co-ordinate an international effort to drive characterization of the human pediatric proteome in health and disease. Early efforts focussed on existing studies in pediatric proteomics, through a special Issue of Proteomics - Clinical Applications in December 2014, Focus on Proteomics in Paediatrics, and a review series in Clinical Proteomics from November 2015 to April 2016.


    The current co-chairs, Vera Ignjatovic (Murdoch Childrens Research Institute, Australia), Hanno Steen (Boston Children’s Hospital, USA) and Allen Everett (Johns Hopkins, USA) have developed a list of goals for the HPP-PediOme, including:

    • To create a worldwide pediatric biorepository network and inventory
    • To standardize the protocols for pediatric specific proteomic studies
    • To facilitate training, as well as collaboration between clinicians and scientist, thereby enable translation of outcomes.


    Ultimately, the PediOme Project aims to fully characterize the healthy pediatric proteome from birth until adulthood, and to utilize the knowledge of the pediatric proteome for the prevention of major adult diseases such as cardiovascular disease, diabetes and obesity. For more information and to participate, please visit HPP-PediOme, or contact one of the co-chairs. 

  • 05 Jun 2017 11:22 AM | Anonymous member (Administrator)

    HUPOST: Where does your interest in quality control come from?

    DT: I’ve been in bioinformatics for twenty years now, and I have come to realize that black boxes harm users as well as bioinformaticists. I have therefore started to dedicate quite a bit of time to bioinformatics education. Many researchers in proteomics and metabolomics simply do not know the extent to which technical variation may be hiding biological variation in their experiments, so quality control represents a look inside the black box of these important methods.

    HUPOST: Can you tell us  a bit more about the HUPO PSI Quality Control Working Group?

    DT: The Quality Control Working Group (QC WG) is the first new Working Group of the HUPO Proteomics Standards Initiative in over a decade. It joins long-standing Working Groups such as the Mass Spectrometry and Proteomics Informatics Working Groups, which are responsible for mzML and MzIdentML/mzTab, respectively.

    DT: The QC WG is a group of researchers from proteomics and metabolomics that is dedicated to see quality control mature as a research discipline.  We must ensure that QC is accessible to people who may not be familiar with the intricacies of standard formats and statistical models. The focus of the QC WG, therefore, is on making quality control a part of everyday practice.

    HUPOST: Who should be interested in the Quality Control Working Group?

    DT: I strongly believe that quality control is of interest to everyone in the field. Just because something is not dramatic does not mean it’s non-essential. When I think about the ways in which our work can be useful, I think about a principal investigator writing a solid research proposal, about a core facility director who wants to deliver top-notch service, and about a technician besieged by people who want their data “yesterday.” All of them need quality control, and we hope to arm these people with useful tools. The focus is currently on quality control for mass spectrometry, but the scope within this field is very broad, and includes both proteomics and metabolomics applications.

    HUPOST: What are the desired outcomes of the work of the Quality Control Working Group?

    DT: The primary target in our sights is interoperability; if a researcher creates a new set of quality control metrics, we want the output of the tool that calculates these metrics to be compatible with a statistical tool that was originally built to analyze another set of QC metrics. The qcML standard format for quality control metrics is at the core of this endeavour. To put it another way, quality control information is the commodity that we want to trade among metric generation software, statistical frameworks and repositories, with qcML as the coinage.

    DT: Practically, this will require tools that generate metrics (for instance, QuaMeter and OpenMS) to produce qcML as output on the one hand, and statistical frameworks that can read and digest qcML on the other hand.

    DT: Moreover, the objective of these statistical models should be to make tangible decisions based on these data, such as flagging an experiment as an outlier. Here, reliability is key. If a given tool repeatedly informs a technician that something is out of whack, the tech will quickly learn to ignore it if there are too many false positives.

    DT: And of course, we endeavour to lower thresholds for adoption of quality control in everyday practice; the less effort required to emplace quality control regimen, the more likely people are to put it into use.

    HUPOST: What would you say to prospective participants in the Quality Control Working Group to raise their interest?

    DT: First and foremost, like all PSI Working Groups, the QC WG is always open to participation! The group consists of people who are very invested in quality control, who frequently bounce ideas off each other.

    DT: But more than this, the QC WG really does need your insights; not only to learn what users require, but also your insights into statistics to harvest conclusions and decisions from quality control data. We also need the input from vendors; ideally their instrument control software would produce qcML directly to support assessment of these workflows, and vendors have great insights into the workflows that are right around the corner for our field!

    DT:If you’re interested in participating, there’s a monthly Google Hangouts call, a QC WG GitHub repository, and a mailing list. Of course, the QC WG’s web page is also a good place to start.

    HUPOST: What is the Quality Control Working Group working on right now?

    DT: When qcML was first published, it was built around the available knowledge at the time. We are now extending qcML to accommodate a broader range of experiment types (such as selected reaction monitoring and data-independent acquisition). To achieve this, we need to address two challenges: how do we broaden the scope of qcML into new types of experiments, and how prescriptive should the QC WG be with regards to the description of quality control metrics? At our most recent meeting in Beijing in April, we came to the conclusion that a developer needs to have access to concise reading materials that allows them to create a valid and useful qcML quickly. It should not be necessary to understand the HUPO PSI working method and development process to be able to write a functional qcML file.

    DT: Both of these challenges again boil down to lowering thresholds to adoption: making sure that quality control can easily be applied to your experiments, regardless of their type, and enabling developers to quickly and easily adopt qcML in their software.

    HUPOST: Does the Quality Control Working Group have a presence at the 2017 HUPO Conference in Dublin?

    DT: Of course! There will be an overall PSI session at the conference, and we are always well represented in the Bioinformatics Hub as well.

    HUPOST: Thank you very much, and we wish the Quality Control Working Group a bright future!

  • 05 Jun 2017 11:15 AM | Deleted user

    1. Human Brain Proteome Project (HBPP)

    Garcez et al. Sci Rep. 2017 Jan 23;7:40780. doi:10.1038/srep40780. Zika virus disrupts molecular fingerprinting of human neurospheres.

    Combining proteomics and mRNA transcriptional profiling, we found over 500 proteins and genes associated with the ZIKV infection in neurospheres associated to impairments in the cell cycle and neuronal differentiation. Our results point to biological mechanisms implicated in brain malformations, which could be exploited as therapeutic potential targets to mitigate it.

    2. Human Immuno-Peptidome Project (HIPP)

    Abelin JG, Keskin DB, Sarkizova S, Hartigan CR, Zhang W, Sidney J, Stevens J, Lane W, Zhang GL, Eisenhaure TM, Clauser KR, Hacohen N, Rooney MS, Carr SA, Wu CJ. (2017). Mass Spectrometry Profiling of HLA-Associated Peptidomes in Mono-allelic Cells Enables More Accurate Epitope Prediction. Immunity 46:315-326.

    HLA class I binding prediction has traditionally been based on biochemical binding experiments. Abelin and colleagues present an LC-MS/MS workflow and analytical framework that greatly accelerates gains in prediction performance. Key advances include the discovery of sequence motifs and improved quantification of the roles of gene expression and proteasomal processing. 

    Workshop Report from 8th Workshop on Affinity Proteomics, Jochen Schwenk

    The 8th Workshop on Affinity Proteomics was held in Alpbach, Austria from March 12th-15th. The meeting brought together more than 130 attendants and recent advances in the generation and use of binding reagents. A broad range of applications were presented including expanded use of microarray and immunoassay systems, as well as mass spectrometry based assessment of antibody selectivity. A panel of researchers, reagent providers and journal editors then discussed the challenges and opportunities of the field today and how to address these for the years to come. 

    This included the need to: 

    • validate the affinity reagent in and for a specific application and sample context
    • provide transparent information about validation (e.g. accessibility to primary data)
    • collect trackable information about affinity reagent (e.g. origin, LOT and product number, clone or sequence)
    • standardise the assessment criteria and assays

    The 9th Workshop on Affinity Proteomics is planned to be held in Alpbach in two years.

    Upcoming Workshops:

  • 05 Jun 2017 11:03 AM | Anonymous member (Administrator)

    The HUPO 2017 Conference in Dublin is host to several pre-conference workshops and events on Sunday 17 September, one of which is a repeat of the acclaimed Mentoring Day (you can find a report on last year’s Mentoring Day in the B/D-HPP Newsletter). We were eager to find out more about this event, and we therefore spoke with representatives from the three organizing groups:

     HUPOST: Can you tell us something about the group you represent, and about the link between the group and the Mentoring Day?

    MD: YPIC was founded by EuPA to represent young investigators in proteomics, and to address their specific needs. We surveyed these needs, and we found that the responses meshed very well with what he Mentoring Days at previous HUPO Conferences (Vancouver 2015, and Taipei 2016) was covering. As a result, we contacted HUPO’s ECR to join them in organizing the Mentoring Day at HUPO 2017 in Dublin.

    JFB: The HUPO ECR was founded at HUPO 2015 in Vancouver, under the auspices of the Biology/Disease Human Proteome Project Excecutive Committee. The goal of the HUPO ECR Initiative is to transmit the HUPO ideals to the next generation of proteomics leaders. And mentoring represents one of the strongest links between generations of researchers. The Mentoring Day was therefore conceived as a combination of lectures and brainstorming sessions to provide young scientists with concrete examples and tips on how to build a career in proteomics.

    VS: EuBIC is a group of young researchers that are active in the field of computational proteomics. This group is very much focused on the needs of proteomics researchers, and therefore aims to provide educational materials and workshops to bring the bioinformatics and proteomics communities closer together. For the Mentoring Day, EuBIC especially wants to help young proteomics researchers in handling their bioinformatics, which can quickly become an important issue in the ever more complex experiments performed today.

    HUPOST: What exactly can participants expect from the Mentoring Day?

    JFB: The Mentoring Day physically brings established proteomics experts and early-career proteomics researchers together in a friendly and informal atmosphere. Young researchers can learn from their shared experiences, ask questions, get advice, and present themselves. The Mentoring Day is very interactive, and consists of sessions aimed at personal and career development opportunities, through panel discussions with industry, brainstorm sessions, and games. A few comprehensive and dynamic talks are added to this exciting mix for inspiration and discussion points. Of course, attendees are encouraged to share their own perspective and to join the debate, all in a friendly and constructive atmosphere.

    MD: At the Mentoring Day, young and established scientists mix in an informal atmosphere. We’ll be discussing the relative merits of careers in industry and academia, the importance of networking and the ways to go about creating such networks, as well as the intricacies of the publication process. The final round table will be an open brainstorm on the future of science, and the role of proteomics in that future.

    VS: The Mentoring Day will also have a special session dedicated to finding answers to bioinformatics problems, and to discuss open data in proteomics.

    HUPOST: Who should join the Mentoring Day?

    JFB: Young researchers without age, experience, or culture limitations. We are trying to cover the needs from Master’s students to young PIs that are starting their own labs.  Our mentors will be sharing their professional knowledge, but also personal advice on, for instance, maintaining a healthy work/life balance.

    MD: The Mentoring Day is open to all interested attendees of HUPO 2017, as there is bound to be something interesting for everyone, regardless of their actual career stage.

    JFB: Exactly! Established researchers and leaders in the field can for instance come to be inspired by the fresh enthusiasm of the young researchers, and can take the opportunity to meet their future students, postdocs or collaborators.

    HUPOST: What are your desired outcomes for the Mentoring Day?

    MD: An ideal outcome for me would be a lively social event at the end of the day, where groups of young and established researchers mix and discuss the topics brought forward during the day, and any other topics they find interesting.

    VS: And through this, we will hopefully be able to boost the confidence of young researchers in taking control of their own career, which includes a deep understanding of the publishing process from the points of view of an author, an editor, and a reviewer. Especially the latter is a complex task that is easily misinterpreted as a call for harsh criticism rather than as a constructive process to help peers perform even better science.

    MD: Precisely! And young researchers can moreover be overwhelmed by the impressive keynote presentations given by well-established researchers at a Conference such as HUPO. It is therefore very important to show them how these established researchers also struggle to produce these wonderful results, and that science can be complicated for everyone.

    JFB: For me, the Mentoring Day should allow early-career proteomics researchers to gain more visibility within the proteomics community, to polish their communication skills, and to learn from someone else's mistakes. Meanwhile, established experts will be able to realize that the times, needs, and opportunities for young researchers have changed.

    HUPOST: What would you say to a prospective participant to convince them to attend the Mentoring Day?

    VS: You know all those questions about science, your career, and your future that you were always afraid to ask? We’ll be discussing and answering these during the Mentoring Day!

    JFB: Come and speak face to face with experts from academia, industry, and bioinformatics. And importantly, we always have sweets available and will hopefully conclude with a lively happy hour after the last session!

    MD: If you do not already know what you will do after your PhD or postdoc, the Mentoring Day will provide you with the information you need to answer that question.

    HUPOST: Do you have any other initiatives ongoing or planned that we should know about?

    JFB: An important currently ongoing ECR activity is the ECR Manuscript Competition. Here, early-career researchers compete with their colleagues from all over the world for their work to be selected among the three best proteomics manuscripts of the year. This competition provides an opportunity to highlight your work, and to present yourself to an international audience. The award(s) will be announced at the HUPO 2017 closing ceremony and the three finalists will receive a monetary price ($1,000 USD for first place, and $500 USD for two runner-ups). Be quick, though, as the application deadline is 5 June 2017! Find out more at: ECR Manuscript  

    MD: YPIC is currently hosting its YPIC Challenge, where participants get mailed a vial with nineteen peptides, which construct a sentence from a book. The challenge is to obtain the sentence, and identify its source. Participants write a small manuscript to describe their efforts, and the best submission wins a EuPA Travel Scholarship, which can be used to attend any EuPA or HUPO conference in the future. While the challenge may sound easy, it is not. For one thing, turning the Oxford Dictionary into a sequence database will not work, and this is therefore de facto a de novo assignment. Oh, and even if you do not have a mass spectrometer available, at least one of the acquired data sets will be shared soon, thus allowing bioinformaticians to start working on the problem as well! Find out more about the YPIC challenge at: YPIC Challenge registration 

    MD: At the HUPO 2017 Conference, YPIC is also organizing Meet the Expert Sessions on Monday 18, Tuesday 19, and Wednesday 20 of June during morning coffee break. Registration will be necessary, and questions are to be pooled in advance. A mailing about these sessions will go out to all registered HUPO 2017 Participants in the next weeks!

    VS: EuBIC will be participating in, and contributing several workshops to, the HUPO 2017 Bioinformatics Hub. EuBIC and YPIC are also planning to launch an Online Proteomics Job Fair for proteomics and proteomics bioinformatics at HUPO 2017, to be hosted on the web site of EuBIC and the EuPA Educational Committee: Proteomics Academy 

    HUPOST: Thank you all very much, and we wish you a sparkling Mentoring Day!

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