The Human Brain Proteome Project (HBPP) is an initiative from and for neuroproteomics researchers working in the fields of neuroscience, neurology, psychiatry, neurosurgery, and brain oncology. HBPP promotes large-scale and targeted state-of-the-art proteome studies on human brain, brain-related body fluids such as CSF, pre-clinical models, and follow up projects to decipher the role of proteins in brain development, health and disease.
Current lines of work:
HBPP Steering Committee
Award For Prof. Daniel Martins-De-Souza
Serrapilheira Institute is the first private nonprofit institution created to promote science and increase its visibility and impact in Brazil.
Their first call was directed to identify and support the best young researchers in Brazil. According to its President, Dr. Hugo Aguilaniu, they looked for those who are posing the big questions in their fields.
There were almost 2000 submitted projects, from which they selected 65. These will receive R$ 100,000.00 (near US$ 31,000.00) for one year. The Institute will selected 10 to 12 out of the 65 to receive R$
1 million (near US$ 310,000.00) for additional three years.
Daniel Martins-de-Souza, member of the HBPP steering committee, is one of the 65 awardees. His project uses neuroproteomics to understand the molecular basis of schizophrenia and to identify protein biomarkers in patients´ blood which could predict antipsychotic response.
The Lab of Neuroproteomics (University of Campinas, Brazil) is a multidisciplinary group that bases their investigation on psychiatric disorders in proteomics. To explain their work to the general public, they created the following video. Lab of Neuroproteomics, UNICAMP, Brazil video.
Elemental fingerprinting of schizophrenia patient blood plasma before and after treatment with antipsychotics. Sussulini A, Erbolato HM, Pessôa GS, Arruda MAZ, Steiner J, Martins-de-Souza D. Eur Arch Psychiatry Clin Neurosci. 2018 Sep;268(6):565-570. doi: 10.1007/s00406-017-0836-4. Epub 2017 Aug 29. PMID: 28852835
Targeted proteomic analysis of cognitive dysfunction in remitted major depressive disorder: Opportunities of multi-omics approaches towards predictive, preventive, and personalized psychiatry. Schubert KO, Stacey D, Arentz G, Clark SR, Air T, Hoffmann P, Baune BT. J Proteomics. 2018 Sep 30;188:63-70. doi: 10.1016/j.jprot.2018.02.023. Epub 2018 Feb 21. PMID: 29474866
Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia. Sullivan CR, Koene RH, Hasselfeld K, O'Donovan SM, Ramsey A, McCullumsmith RE. Mol Psychiatry. 2018 Mar 1. doi: 10.1038/s41380-018-0035-3. [Epub ahead of print] PMID: 29497148
Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry. Barkovits K, Linden A, Galozzi S, Schilde L, Pacharra S, Mollenhauer B, Stoepel N, Steinbach S, May C, Uszkoreit J, Eisenacher M, Marcus K. J Proteome Res. 2018 Oct 5;17(10):3418-3430. doi: 10.1021/acs.jproteome.8b00308. Epub 2018 Sep 12. PMID: 30207155
No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients. Bridel C, Eijlers AJC, van Wieringen WN, Koel-Simmelink M, Leurs CE, Schoonheim MM, Killestein J, Teunissen CE. Front Mol Neurosci. 2018 Oct 31;11:371. doi: 10.3389/fnmol.2018.00371. eCollection 2018. PMID: 30429773
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers. Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.Behav Brain Res. 2018 Mar 15;340:71-80. doi: 10.1016/j.bbr.2016.08.058. Epub 2016 Aug 31. PMID: 27591967
Upcoming B/D-HPP Workshop
29th Human Brain Poteome Project Workshop. May 27-28, 2019, Amersterdam, The Netherlands
HBPP contribution to HUPO 2019, Adelaide
26th HUPO Human Brain Proteome Project Workshop
25th HUPO Human Brain Proteome Project Workshop
27th HUPO Human Brain Proteome Project Workshop
28th The Human Brain Proteome Project (HBPP) Workshop
The South Australian Health and Medical Research Institute (SAHMRI)
For more information or participation opportunities please contact office(at)hupo.org.