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Human Brain Proteome Project


https://www.facebook.com/hbpp1/

Website: 

www.hbpp.org 

The Human Brain Proteome Project (HBPP) is an initiative from and for neuroproteomics researchers working in the fields of neuroscience, neurology, psychiatry, neurosurgery, and brain oncology. HBPP promotes large-scale and targeted state-of-the-art proteome studies on human brain, brain-related body fluids such as CSF, pre-clinical models, and follow up projects to decipher the role of proteins in brain development, health and disease.

Current lines of work:

  • Methodological approaches:
  • Brain tissue based neuroproteomic profiling
  • Cerebrospinal fluid (CSF) neuroproteomic profiling
  • Peripheral blood neuroproteomic profiling
  • Autoimmune profiling of CNS disorders

Clinical areas:

  • Neurodegenerative disorders (e.g. the dementias, movement disorders)
  • Psychiatric disorders (e.g. schizophrenia, bipolar disorder, depressive disorder)
  • CNS cancers
  • Traumatic brain injury

Initiative approach:

  • Connect neuroproteomic scientists and provide opportunities for new collaborations
  • Identify molecular mechanisms and biomarkers involved in neurodegeneration and psychiatry.
  • Understand the environment around the healthy human brain.
  • Develop new strategies and methodological approaches for neuroproteomics
  • Promote quality benchmarks for neuroproteomic research

Main achievements

  • 28th HBPP international workshop, Adelaide (AUS), May 8-9 2018
  • HBPP contribution to HUPO congress (29th HBPP workshop), Orlando (USA), Oct 2018
  • Established DIA-based workflow for CSF and brain tissue (neuronal cells)
  • Established new quality criteria for CSF protein biomarker analysis
  • Developed strategies for clinical, proteome and metabolome data integration
  • Developed strategies for transcriptome and proteome integration for personalized psychiatry

    HBPP Steering Committee

    • Charlotte Teunissen (Chair) VU University Medical Center Amsterdam
    • Katrin Marcus (Co-Chair) Ruhr University, Bochum
    • Daniel Martins-de-Souza, University of Campinas, São Paulo 
    • Helmut E. Meyer, ISAS – Leibnitz-Institut für Analytische Wissenschaften, Dortmund 
    • Peter Nilsson, KTH – Royal Institute of Technology, Stockholm 
    • Oliver Schubert, University of Adelaide 

    Award For Prof. Daniel Martins-De-Souza

    Serrapilheira Institute is the first private nonprofit institution created to promote science and increase its visibility and impact in Brazil.

    Their first call was directed to identify and support the best young researchers in Brazil. According to its President, Dr. Hugo Aguilaniu, they looked for those who are posing the big questions in their fields.

    There were almost 2000 submitted projects, from which they selected 65. These will receive R$ 100,000.00 (near US$ 31,000.00) for one year. The Institute will selected 10 to 12 out of the 65 to receive R$

    1 million (near US$ 310,000.00) for additional three years.

    Daniel Martins-de-Souza, member of the HBPP steering committee, is one of the 65 awardees. His project uses neuroproteomics to understand the molecular basis of schizophrenia and to identify protein biomarkers in patients´ blood which could predict antipsychotic response.

    The Lab of Neuroproteomics (University of Campinas, Brazil) is a multidisciplinary group that bases their investigation on psychiatric disorders in proteomics. To explain their work to the general public, they created the following video. Lab of Neuroproteomics, UNICAMP, Brazil video

    Papers

    Elemental fingerprinting of schizophrenia patient blood plasma before and after treatment with antipsychotics. Sussulini A, Erbolato HM, Pessôa GS, Arruda MAZ, Steiner J, Martins-de-Souza D. Eur Arch Psychiatry Clin Neurosci. 2018 Sep;268(6):565-570. doi: 10.1007/s00406-017-0836-4. Epub 2017 Aug 29. PMID: 28852835

    Targeted proteomic analysis of cognitive dysfunction in remitted major depressive disorder: Opportunities of multi-omics approaches towards predictive, preventive, and personalized psychiatry. Schubert KO, Stacey D, Arentz G, Clark SR, Air T, Hoffmann P, Baune BT. J Proteomics. 2018 Sep 30;188:63-70. doi: 10.1016/j.jprot.2018.02.023. Epub 2018 Feb 21. PMID: 29474866

    Neuron-specific deficits of bioenergetic processes in the dorsolateral prefrontal cortex in schizophrenia. Sullivan CR, Koene RH, Hasselfeld K, O'Donovan SM, Ramsey A, McCullumsmith RE. Mol Psychiatry. 2018 Mar 1. doi: 10.1038/s41380-018-0035-3. [Epub ahead of print] PMID: 29497148

    Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry. Barkovits K, Linden A, Galozzi S, Schilde L, Pacharra S, Mollenhauer B, Stoepel N, Steinbach S, May C, Uszkoreit J, Eisenacher M, Marcus K. J Proteome Res. 2018 Oct 5;17(10):3418-3430. doi: 10.1021/acs.jproteome.8b00308. Epub 2018 Sep 12. PMID: 30207155

    No Plasmatic Proteomic Signature at Clinical Disease Onset Associated With 11 Year Clinical, Cognitive and MRI Outcomes in Relapsing-Remitting Multiple Sclerosis Patients. Bridel C, Eijlers AJC, van Wieringen WN, Koel-Simmelink M, Leurs CE, Schoonheim MM, Killestein J, Teunissen CE. Front Mol Neurosci. 2018 Oct 31;11:371. doi: 10.3389/fnmol.2018.00371. eCollection 2018. PMID: 30429773

    Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers. Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.Behav Brain Res. 2018 Mar 15;340:71-80. doi: 10.1016/j.bbr.2016.08.058. Epub 2016 Aug 31. PMID: 27591967

    Upcoming B/D-HPP Workshop

    29th Human Brain Poteome Project Workshop. May 27-28, 2019, Amersterdam, The Netherlands 

    HBPP contribution to HUPO 2019, Adelaide
    Summerschool “Advanced Proteomics”, August 2019, Brixen, Italy
    Development of top-down MS method for alpha synuclein quantification
    Development of a routine workflow for the implementation of clinical and different omics data for biomarker research


    Past Workshops

    26th HUPO Human Brain Proteome Project Workshop
    During the HUPO 2016 congress in Taipei, Taiwan

    25th HUPO Human Brain Proteome Project Workshop
    May 3-4, 2016 in Stockholm, Sweden
    A summary of the HBPP workshop can be seen here.

    27th HUPO Human Brain Proteome Project Workshop
    May 9-10, 2017 in Bochum, Germany

    28th The Human Brain Proteome Project (HBPP) Workshop
    May 8-9, 2018 in Adelaide, Australia. 

    The South Australian Health and Medical Research Institute (SAHMRI) 


    For more information or participation opportunities please contact office(at)hupo.org.




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