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Proteomics Scientist

01 Dec 2022 12:51 PM | Anonymous

Position Title: Proteomics Scientist
Company: BERG Health
Location: Framingham, MA, USA

BERG Health is seeking a highly motivated Proteomics Scientist who will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry and clinical medicine. This role will join a team responsible for biomarker and target discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer.

Essential Duties and Responsibilities:

  • Spearhead technical analysis of post-translational modifications (phosphorylation, acetylation, ubiquitation, sumoylation etc.). Contribute to the assessment of chemoproteomic analysis for MOA of specific compounds under investigation.
  • Identify the mechanism of action of drugs and drug-like molecules; developing and optimizing novel, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications.
  • Collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
  • Mentor research associates.
  • Other duties as assigned

Requirements:

  • Requires a Ph.D. degree in Biology, Biochemistry, Chemistry or Analytical Sciences with relevant postdoctoral experience and 3-5 years' experience with nanoLC-MSMS analysis using HR/HA mass spectrometry instruments.
  • A strong background in state-of-the-art proteomics, more specifically post-translational modification analysis; some experience in cell biology, signaling and/or systems biology.
  • Familiarity with high-throughput quantitative methodologies such as TMT® and Label-free approaches.
  • Ability to apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds.
  • Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
  • Demonstrated ability to analyze, interpret and present data in a clear fashion.
  • Solid scientific training/productivity as identified through high impact publications demonstrating creative thinking as well as innovative technical approaches.
  • Experience with Thermo/Bruker instrumentation platforms is a plus.

Link to full description: https://www.berghealth.com/careers/

Twitter, Facebook and Linkedin account information (including handles and links): https://www.berghealth.com/

Contact information: Michael Kiebish (Michael.kiebish@berghealth.com) – hiring manager




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