The University of Southern Denmark: Postdoc Position in Characterization of Non-Alcoholic SteatoHepatitis (NASH) Using Clinical Proteomics and PTMomics at Department of Biochemistry and Molecular Biology
Main objectives of the postdoc project (three years):
- To identify circulating proteins (or specific PTMs) that correlate with key features of liver histopathology, primarily fibrosis, inflammation and/or hepatocyte ballooning, in the context of NASH in rodent and/or hepatocellular or liver tissue ex vivo models.
- To explore the biological mechanism/s of action of key factor/s in the pathogenesis or resolution of NASH in in vitro and/or in vivo models.
- To validate these factor/s in human clinical cohorts to determine their predictive validity in identifying NASH patients and/or with NASH resolution in clinical trial cohorts or subsets of human subjects.
- To perform methodological developments within the clinical proteomics field and in PTMomics characterization of cellular signalling pathways.
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Deadline: 1 March 2019