Position title: Scientist
Location: La Jolla CA
Summary of position: You will be a key contributor to multi-disciplinary project teams supporting early discovery programs through establishing MS-based assays to enable the discovery and development of high-quality small molecule therapeutics. A majority of your work will be lab-based, focused on the exploration, development and implementation of innovative MS techniques to characterize small molecule-protein interactions in living systems and to address other novel scientific questions. The job will entail establishing robust sample preparation protocols and developing targeted and untargeted MS acquisition methods suited for quantitative analysis of peptide analytes within complex peptide mixtures derived from biological matrices. We offer the opportunity to join a dynamic and energetic team of qualified colleagues working in a leading CNS specialized drug discovery organization. The group is well-supported with multiple Orbitrap mass spectrometers, including an Orbitrap Fusion Lumos, and a high-performance cluster for data analysis. A dedicated computational biologist will support proteomics data analysis, curation and management through automated pipelines and through maintenance of a proprietary chemoproteomic database facilitating tracking and mining of all internal proteomics data. The group is actively engaged in both drug discovery and basic research at the frontiers of neuroscience and you will have the opportunity to collaborate and publish with world-class academic labs as highlighted in Cell reports, 31(12), 107805.
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