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Human Liver Proteome Project (HLPP)

The liver is a central organ in human body that controls metabolic homeostasis, provide essential substances to the organism and allow detoxification of xenobiotics. In addition to its biological function, liver physiology is peculiar in different aspects, including its regeneration capacity. Despite the intense research performed during the last couple of decades, there are still many open questions in regard of the molecular mechanisms underlying liver function and, most importantly, liver disease. This constraint largely restricts the development of more efficient diagnostic and therapeutic strategies for the better management of the patients. In the postgenomic era, the Human Liver Initiative started in 2002 as a large-scale international collaborative initiative aiming to define a comprehensive and dynamic map of the human liver proteome.

Current lines of work:

  • Definition of liver proteome by characterization of all specific liver cell types and their interaction in health and disease.
  • Definition of priority protein lists relevant in liver physiology and participating in the molecular pathogenesis of liver disorders. Example: panel of 15 enzymes of One Carbon Metabolism.
  • To develop targeted standardized methods for the quantification of clinically relevant proteins. Example: SRM assay for a panel of 12 enzymes of One Carbon Metabolism.
  • In depth dynamic characterization of liver regeneration by a combination of proteomics and phosphoproteomics.
  • To identify novel proteins relevant in liver biology and pathology by means of proteogenomics.
  • Identify differentially expressed proteins in Hepatocellular carcinoma (HCC) patients who underwent liver transplantaion, using proteomics of vascular invation, well differentiated, moderate differentiated, and poor differentiated liver biopsies
  • Non Alcoholic Fatty Liver Disease (NAFLD) molecular characterization and early marker discovery.
  • Analysis of molecular mechanisms in drug induced liver injury.
  • To study the role of ubiquitin-like proteins in liver disease.


Related web-address links:

European Association for the Study of the Liver: www.easl.eu

Links to other HPP groups:

Participating chromosomes: 1, 8, 16

Leadership:

  • Fernando J. Corrales, Chair
  • Pumin Zhang, Co-chair

Upcoming Meetings:

  • C-HPP Symposium. May 12-14, 2019
  • XIV annual Meeting of the Italian Proteomics Association. June 25-27, 2019.
  • 18th HUPO World Congress. September 15-18, 2019.

Publications:

For more information or participation opportunities please contact office(at)hupo.org.




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