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Human Liver Proteome Project (HLPP)

The liver is a central organ in the human body that controls metabolic homeostasis, provides essential substances to organisms, and allows for the detoxification of xenobiotics. In addition to its biological function, liver physiology is peculiar in different aspects, including its regeneration capacity. Despite the intense research performed during the last couple of decades, there are still many open questions regarding the molecular mechanisms underlying liver function and, most importantly, liver disease. This constraint largely restricts the development of more efficient diagnostic and therapeutic strategies for the better management of patients.  In the postgenomic era, the Human Liver Initiative started in 2002 as a large-scale international collaborative initiative aiming to define a comprehensive and dynamic map of the human liver proteome.

Current lines of work:

  • Definition of the liver proteome by characterization of all specific liver cell types and their interaction in health and disease.
  • Definition of priority protein lists relevant in liver physiology and participating in the molecular pathogenesis of liver disorders.
  • To develop targeted standardized methods for the quantification of clinically relevant proteins.
  • To identify novel proteins relevant in liver biology and pathology by means of proteogenomics.

Related web-address links:

European Association for the Study of the Liver: www.easl.eu

Links to other HPP groups:

Participating chromosomes: 1, 8, 16


  • Fernando J. Corrales, Chair
  • Pumin Zhang, Co-chair


For more information or participation opportunities please contact office(at)hupo.org.

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