The HUPO and HPP Executive Committees are pleased to announce that Pathology will join Mass Spectrometry, Antibodies and Knowledgebases as another pillar of the Human Proteome Project (HPP). The introduction of the Pathology Pillar acknowledges the key roles that pathology will play in the delivery of proteomics-driven biomarker discovery for clinically useful diagnostic assays. It also recognizes the fundamental importance of new proteomic assays for the on-going development of precision medicine. The Pathology Pillar will co-ordinate the identification of key unmet needs in clinical medicine, stimulate guidelines and standards for the development of fit-for-purpose validated clinical assays, promote awareness of best practice and coordinate access to bioresources of clinical samples with its associated data. It will also assist in HUPO’s expansion of partnerships with international pathology organizations, diagnostic industries and regulatory agencies. The HPP Pathology Pillar will be launched and highlighted in September at the HUPO2018 World Congress in Orlando, USA.