POSITION/TITLE:  Research Assistant in Proteomics
ORGANIZATION:  Centre for Medicines Discovery, NDM Research Building, Old Road Campus
LOCATION: Headington, Oxford, UK

The Discovery Proteomics at the Centre for Medicine Discovery / Target Discovery Institute/ Nuffield Department of Medicine in University of Oxford has a position opened for a research assistant position. If you are interested, don’t hesitate to apply. The closing date is the 31^st of Oct.

View here for all details.

POSITION/TITLE: Joint PhD position
COMPANY: Lilley Lab (Cambridge) and Nita-Lazar Lab (NIH) through the NIH-Oxford/Cambridge Scholars Program
LOCATION: United Kingdom/USA (the students in the OxCam program are spending 2 years in each location)

Summary of Position:

The NIH-Oxford/Cambridge Scholars program offers the chance for US citizens and permanent residents to carry out dual center PhD programs between the US and Cambridge/Oxford University labs.

The Nita-Lazar and Lilley labs are offering the exciting opportunity to carry out a joint project through this scheme as follows:

The aberrant modification status of proteins is universally recognized as a crucial component of disease. In order to develop therapeutic agents to combat disease, we need to understand the role that posttranslational modifications (PTMs) play within pathological systems, particularly filling in gaps in our knowledge of the effect of aberrant PTMs on subcellular localization. Focusing on infectious diseases using mutant cell lines, mouse models and patient data we will study the link between PTM status and subcellular location which has been so far poorly captured in the majority of experimental workflows. The knowledge of the PTM affecting relocalization of the protein and, in turn, its function, may be pivotal to the correct drug design. This project combines development of state of the art quantitative proteomics methodologies, computational workflows and whole cell modelling which will be used to decipher the mechanism of immunity to infection and propose new ways of treatment.

Interested candidates should apply through the website (deadline for the Fall 2025 admissions is December 2, 2024)

More information on the position and application details: https://oxcam.gpp.nih.gov/prospective-students/how-apply

For questions, please contact Kathryn Lilley (k.s.lilley@bioc.cam.ac.uk) or Aleksandra Nita-Lazar (nitalazarau@niaid.nih.gov). In-person inquiries at the HUPO 2024 Conference in Dresden are welcome.

POSITION/TITLE:  Lead OR Principal Bioinformatics Research Scientist 
COMPANY:  St. Jude Children's Research Hospital 
LOCATION:  Memphis, TN, USA

Summary of Position:
Please see job Link here for any and all information about the position:
https://stjude.wd1.myworkdayjobs.com/stjude/job/Memphis-TN/Lead-OR-Principal-Bioinformatics-Research-Scientist_JR3493-1 

Link to Full Job Description:
See above link.

X, Facebook and LinkedIn account information (including handles and links):

• https://www.facebook.com/stjude
• https://www.linkedin.com/company/st-jude-childrens-research-hospital
• https://x.com/StJudeResearch

Contact Information:
Please refer to the following application link: https://stjude.wd1.myworkdayjobs.com/stjude/job/Memphis-TN/Lead-OR-Principal-Bioinformatics-Research-Scientist_JR3493-1?source=Niche&utm_source=Niche&utm_medium=job-posting

POSITION/TITLE: PhD fellow and/or Post Doctoral fellow
COMPANY: University of Copenhagen
LOCATION: Copenhagen, Denmark

Summary of Position:

The Cardiac Proteomics Group at Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen seeks to appoint a talented PhD fellow and Post Doctoral Fellow to outline protein regulations involved in the pathogenesis of cardiometabolic syndrome. The fellows will investigate remodeling in hearts from animal models, patient heart samples as well as cell systems using quantitative proteomics-based approaches to identify molecular changes driving the disease state. We are seeking highly motivated scientists to join our team. Prior experience with mass spectrometry based proteomics -either experimentally or analytically- is required.

More information on the PhD fellow position here:
https://employment.ku.dk/phd/?show=162530

More information on the post doctoral fellow position here:
https://employment.ku.dk/faculty/?show=162531

Application closing date: November 1st  2024, 01/11/2024

POSITION/TITLE:  Senior Scientist
LOCATION:  North West England

Job Summary

Seeking a Senior Scientist to support the development of clinical assays for biomarkers arising from a proteomics biomarker discovery platform. The candidate will be involved in a variety of projects that aim to expand the portfolio of proteomic and phosphoproteomic assays, and to develop these into new clinical products. The ideal candidate for this role will have a PhD (or equivalent experience) in a relevant field with expertise in developing targeted mass spectrometry-based assays on triple quadrupole instruments.

This role will be based full time at our Cheshire lab and will have responsibilities to both the LC-MS/MS team and a newly formed product development team aiming to take biomarkers from research setting to clinical labs. The role will report to the Mass Spectrometry Technical Lead as well as interact closely with the Head of Product. Current LC-MS/MS capabilities include a Thermo Orbitrap Exploris 240 mass spectrometer, coupled to a Vanquish Neo UHPLC, a Thermo Altis Plus triple quadrupole mass spectrometer coupled to a Vanquish Neo UHPLC and a ZenoTOF 7600 coupled to a Waters ACQUITY M-Class UPLC. The number and range of LC- MS/MS systems required is likely to increase as methods diversify and sample numbers increase.

Responsibilities and Duties

Development of clinically applicable targeted assays

• Develop targeted LC-MS methods on a triple quadrupole mass spectrometer to accurately and robustly quantify peptide biomarkers arising from research.
• Devise strategies for normalisation and quality control to ensure tests are accurate, reproducible and reliable and to ensure we adhere to the relevant quality standards.
• Work with the product development team and quality manager to ensure appropriate systems, monitoring and documentation is in place during development of a test which can ultimately be relied upon to aid patient treatment decision making.
• Author and/or contribute to regulatory submissions, technical protocols and reports.

General LC-MS/MS operation and maintenance

• Work with the Mass Spectrometry Technical Lead to ensure that LC-MS/MS systems are regularly maintained and calibrated, that all buffers are properly prepared and regularly replaced, and to ensure that the proper Quality Control samples are run, and robust checks are in place.
• Outputs of all maintenance, calibrations, QC work are to be documented for reporting purposes.
• To make process improvements and project efficiencies wherever possible and to contribute freely to the team environment in a manner conducive to the success of company goals.
• To work as part of a lab-based team, being mutually supportive and covering duties as necessary during colleagues’ absences and at times of additional pressure, as directed.

The above list of responsibilities is not exhaustive, and the jobholder may be required to undertake other duties commensurate with the level of the role, as reasonably requested by their manager.

Qualifications, Experience and Skills

Essential

• PhD (or equivalent experience) in a relevant or STEM based subject.
• ≥2 years of hands-on experience running/operating high-end LC-MS/MS systems (including hands- on experience calibrating the MS systems, basic maintenance of LC-MS/MS, renewing buffers, running QCs, interpreting data, and reporting QC outputs).
• Specific experience running triple quadrupole mass spectrometers and developing targeted methods.
• Expertise developing clinical assays utilising LC-MS/MS proteomic technologies.
• Experienced interrogating LC-MS/MS raw data using vendor software (e.g., Thermo’s Xcalibur/Freestyle/Chromeleon, or SciexOS).
• Ability to work to timelines.
• Excellent communication skills and teamwork skills.
• Excellent organisational skills and time management skills.
• Ability to contribute to the team success.
• A high degree of personal motivation and a willingness to learn new skills, take on challenges and undertake relevant training.

Non-essential, but added advantage

• Experience with quality management systems and documentation.
• Experience in developing and validating mass spec instrumentation and methods.
• Experience working to ISO 15189, CLIA or working in a similar regulated environment.
• Knowledge of medical device design control processes.
• Experienced in preparing samples using proteomic workflows for LC-MS/MS analysis.
• Knowledge and understanding of fundamental principles of biochemical and molecular biological systems.
• Expertise in the utilisation of LC-MS/MS proteomic technologies for the identification and validation of clinical biomarkers.

FOR MORE INFORMATION:
David Britton:  d.britton@globalproteomics.com