B/D HPP
Mission of the Biology/Disease-driven Human Proteome Project (B/D-HPP)
The B/D-HPP is one of the two central pillars of the Human Proteome Project (HPP), alongside the Chromosome-centric HPP (C-HPP). Together, these initiatives aim to comprehensively map and functionally annotate the human proteome.
B/D-HPP brings together a network of specialized initiatives and experts focused on different biological systems and diseases. By aligning proteomics efforts with defined biological contexts and disease phenotypes, the project ensures that discoveries translate into meaningful scientific and clinical impact.
We provide a framework for coordinating biology- and disease-based research contributions to the HPP as described in Aebersold et al. JPR, 2013, Aebersold et al. Proteomics, 2014, Van Eyk et al. JPR, 2016, and the annual HPP metrics report (Deutsch et al., JPR, 2025).
Resources
What we promote
- Expanding functional knowledge of the human proteome in health and disease.
- Integrating proteomics with biology and medicine, studying protein structure, function, interactions, and regulation.
- Supporting disease-focused discovery for biomarkers, therapeutic targets, and drug development.
Our Anticipated Impact
B/D-HPP bridges discovery proteomics and translational research, delivering insights into molecular mechanisms of disease, identifying new diagnostic and therapeutic opportunities, and aligning proteomics research with global health priorities. By coordinating specialized initiatives, the project maximizes the biological and clinical value of proteomics research and contributes to a more complete, functionally annotated human proteome.
Leadership Information
Chair: Bogdan Budnik, Wyss Institute, USA; Bogdan.Budnik@wyss.harvard.edu
Co-chair: Claudia Ctortecka, Northwestern University, USA; Claudia.ctortecka@northwestern.edu
Ferdinando Cerciello, Universität Bern, Switzerland
Anthony Gramolini, University of Toronto, Canada
Edouard Nice, Monash University Australia
Francis O’Reilly, St. Jude Children’s Research Hospital, USA
Zilu Ye, Chinese Academy of Medical Sciences, China
Livia Rosa, University of Sao Paulo, Brazil
Initiative Structure
Cardiovascular Initiative:
Maggie Lam, Ph.D. – University of Colorado, Aurora, CO, USA
Rebekah L. Gundry, Ph.D. – University of Nebraska Medical Center, Omaha, NE, USA
Human Brain Proteome Project:
Daniel Martins-de-Souza, Ph.D. – University of Campinas, Sao Paulo, Brazil
Melanie Föcking, Ph.D. – Royal college of surgeons, Dublin, Ireland
Human Cancer Proteome Project:
Hui Zhang, Ph.D. – John Hopkins University, Baltimore, USA
Ed Nice, Ph.D. – Monash University, Melbourne, Australia
Connie Jimenez, Ph.D. – Amsterdam University, Amsterdam, The Netherlands
Tiannan Guo, Ph.D. – Westlake University, Hangzhou, Zhejiang, China
Human Eye Proteome Project (EyeOME):
Richard D. Semba, Ph.D. – John Hopkins University, Baltimore, USA
Marius Ueffing, Ph.D. – University of Tuebingen, Germany
Hyewon Chung, Ph.D. – Seoul National University, South Korea
Human Glycoproteomics Initiative:
Morten Thaysen-Andersen, Ph.D. – Macquarie University, Sydney, Australia
Daniel Kolarich, Ph.D. – Griffith University, Gold Coast, Australia
Nicolle H Packer, Ph.D. – Macquarie University, Sydney, Australia
Human Immuno-Peptidome Project (HIPP):
Nicola Ternette, Ph.D. – The University of Dundee, United Kingdom
Jennifer G. Abelin, Ph.D. – Broad Institute & Dana-Farber Cancer Institute, Cambridge, MA, USA
Human Liver Proteome Project (HLPP):
Fernando J. Corrales, Ph.D. – Spanish Research Council, Spain
Pumin Zhang, Ph.D. – First Affiliated Hospital of China Medical University, China
Human Plasma Proteome Project (HPPP):
Jochen Schwenk, Ph.D. – SciLifeLab and KTH Royal Institute of Technology, Stockholm, Sweden
Eric Deutsch, Ph.D. – Institute for Systems Biology, Seattle, USA
Initiative for Model Organisms Proteomics (iMOP):
Fabrice Bertile, Ph.D. – CNRS/University Strasbourg, France
Sabine Matallana-Surget, Ph.D. – University of Stirling, UK
Susana Cristobal, Ph.D. – Linköping University, Sweden
Andreas Tholey, Ph.D. – Kiel University, Germany
Jean Armengaud, Ph.D. – Paris-Saclay University, CEA, France
Metaproteomics Initiative:
Tim Van Den Bossche, Ph.D. – Ghent University, Belgium
Benoit Kunath, Ph.D. – University of Luxembourg, Luxembourg
Single Cell Proteomics Initiative:
Claudia Ctortecka, Ph.D. – Northwestern University, IL, USA
Erwin Schoof, Ph.D. – Technical University of Denmark, Denmark
Rheumatoid Arthritis Disorders Initiative:
Francisco J Blanco, MD, Ph.D. – University of A Coruña, Spain