The Human Proteome Project (HPP) is an international project organized by the Human Proteome Organization (HUPO) that aims to revolutionize our understanding of the human proteome via a coordinated effort by many research laboratories around the world.

It is designed to map the entire human proteome in a systematic effort using currently available and emerging techniques. Completion of this project will enhance understanding of human biology at the cellular level and lay a foundation for development of diagnostic, prognostic, therapeutic, and preventive medical applications.

Key Achievements

• Publications of yearly HPP Metrics publications
• Publication of the HPP Mass Spectrometry Data Interpretation Guidelines 3.0
• Launch of the HPP Grand Challenge Project – a function for every protein

In the Pipeline

• Development of the 2026 HPP Metrics manuscript
• Formation of the protein function scoring working group
• Joint projects and initiatives with the HUPO community focusing on studying protein function

Year the initiative was established: 2011