POSITION/TITLE: Joint PhD position
COMPANY: Lilley Lab (Cambridge) and Nita-Lazar Lab (NIH) through the NIH-Oxford/Cambridge Scholars Program
LOCATION: United Kingdom/USA (the students in the OxCam program are spending 2 years in each location)
Summary of Position:
The NIH-Oxford/Cambridge Scholars program offers the chance for US citizens and permanent residents to carry out dual center PhD programs between the US and Cambridge/Oxford University labs.
The Nita-Lazar and Lilley labs are offering the exciting opportunity to carry out a joint project through this scheme as follows:
The aberrant modification status of proteins is universally recognized as a crucial component of disease. In order to develop therapeutic agents to combat disease, we need to understand the role that posttranslational modifications (PTMs) play within pathological systems, particularly filling in gaps in our knowledge of the effect of aberrant PTMs on subcellular localization. Focusing on infectious diseases using mutant cell lines, mouse models and patient data we will study the link between PTM status and subcellular location which has been so far poorly captured in the majority of experimental workflows. The knowledge of the PTM affecting relocalization of the protein and, in turn, its function, may be pivotal to the correct drug design. This project combines development of state of the art quantitative proteomics methodologies, computational workflows and whole cell modelling which will be used to decipher the mechanism of immunity to infection and propose new ways of treatment.
Interested candidates should apply through the website (deadline for the Fall 2025 admissions is December 2, 2024)
More information on the position and application details: https://oxcam.gpp.nih.gov/prospective-students/how-apply
For questions, please contact Kathryn Lilley (k.s.lilley@bioc.cam.ac.uk) or Aleksandra Nita-Lazar (nitalazarau@niaid.nih.gov). In-person inquiries at the HUPO 2024 Conference in Dresden are welcome.
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