HUPO Association

B/D HPP
Human Eye Proteome Project (EyeOME)

GET INVOLVED: Get in touch at office@hupo.org to learn more
Mission & Goals

The general aims of the EyeOME are: 
(i) to develop tools for the identification and quantification of proteins in the human eye, and to apply these tools to identify disease pathways that will lead to new therapeutic interventions and biomarkers for the prevention and treatment of blinding eye diseases; 
(ii) to build a network and community of scientists who will work together and facilitate common interests in the application of proteomics to eye diseases; 
(iii) to characterize the proteome of the normal human eye during the entire life cycle, including protein variants and PTMs; 
(iv) to establish standard operating procedures for study of the human eye proteome, such as the processing, dissection, and storage of eye bank eyes, collection of tears, aqueous humor, and vitreous, collection of ocular tissues during surgery, and storage of samples; 
(v) to establish standards for the reporting of proteomic data in order to develop a high-confidence human eye proteome database; 
(vi) to establish repositories of human samples to facilitate exchange and collaboration; 
(vii) to collect eye proteomedata and research protocols from members for open access; 
(viii) to raise funds for exchange of postdoctoral fellows, symposia at HUPO, and collaborative symposia with the Association for Research in Vision and Ophthalmology (ARVO). A comprehensive proteomics analysis of the human iris tissue: ready to embrace postgenomics precision medicine in ophthalmology.

Leadership Information

Chair:
Richard D. Semba, MD, MA, MPH
Johns Hopkins School of Medicine, Baltimore, USA 

Chair:
Marius Ueffing, MD, Ph.D
Centre for Ophthalmology, University of Tübingen, Germany 

Chair:
Hyewon Chung, MD, Ph.D
Konkuk University Medical Center​, Seoul, Republic of Korea 

Current Lines of Work:

  • Characterization of all subproteomes of the human eye
  • Development of selected reaction monitoring assays for proteoforms implicated in major eye diseases
  • Use of existing formalin-fixed, paraffin-embedded eye tissues for discovery proteomics

Papers:

The Human Eye Proteome Project: Updates on an Emerging Proteome
Combined Targeted Analysis of Metabolites and Proteins in Tear Fluid With Regard to Clinical Applications
Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration
A Comprehensive Proteomics Analysis of the Human Iris Tissue: Ready to Embrace Postgenomics Precision Medicine in Ophthalmology?
The proteome of normal human retrobulbar optic nerve and sclera
Defining the proteome of human iris, ciliary body, retinal pigment epithelium, and choroid
Proteomic insight into the molecular function of the vitreous
Priorities and trends in the study of proteins in eye research, 1924-2014
The proteome of human retina
Exosomal proteins in the aqueous humor as novel biomarkers in patients with neovascular age-related macular degeneration
The Human Eye Proteome Project: perspectives on an emerging proteome

Other HUPO INITIATIVES:

Industrial Advisory Board (IAB) Members

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