The HLPP is a major international initiative dedicated to creating a comprehensive map of the human liver proteome. Its core purpose is to systematically identify and catalogue all liver proteins, including their various forms, modifications, and interactions, while mapping their spatiotemporal localization in both health and disease.

By correlating these protein expression patterns with conditions like hepatitis, cirrhosis, and cancer, the HLPP aims to fundamentally enhance our understanding of liver biology and disease mechanisms. This foundational knowledge is critical for discovering novel biomarkers for early diagnosis and for identifying new therapeutic targets.

The project’s importance lies in its commitment to advancing precision medicine for liver diseases, ultimately paving the way for improved diagnostics, personalized treatments, and preventative strategies through the development of a public database and the fostering of global collaborative networks.

In the pipeline:

• To identify and catalog all proteins expressed in the human liver, including their isoforms and post-translational modifications.
• Discover and validate new biomarkers for liver diseases facilitating early diagnosis, prognostic risk assessment and treatment decision.
• To identify and validate the drug-targetable proteins for further targeted treatment of liver diseases.
• Database Development: Create a publicly accessible database of the liver proteome, including protein sequences, structures, functions, and associated clinical data.
• Establish international collaborations with researchers, clinicians, institutions and industries to share knowledge, resources, and technologies, enhancing the project’s impact and reach.

We gratefully acknowledge all investigators, clinicians, patients, and collaborating institutions who have contributed to advancing the HLPP through data generation, technology development, and translational research. We especially thank the international partners within the Human Proteome Organization and the Human Liver Proteome Project community for their continuous leadership in standardizing liver proteomics, promoting multi-omics integration, and fostering global data sharing.

As liver diseases—including viral hepatitis, metabolic dysfunction–associated steatotic liver disease, cirrhosis, and hepatocellular carcinoma—remain major global health burdens, we warmly encourage research groups, clinicians, bioinformaticians, and industry partners worldwide to join HLPP. By contributing high-quality liver proteomic datasets, innovative technologies, and collaborative expertise, new partners can help accelerate the construction of comprehensive human liver proteome maps, advance biomarker discovery, and promote precision medicine for liver diseases.