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Biology & Disease-driven human proteome project (B/D-HPP)

Musculo Skeletal Immuno Peptidome Human Glycoproteomics Initiative Plasma

Mission of the B/D-HPP

One of the two main programs of the Human Proteome Project is the Biology/Disease-driven Human Proteome Project (B/D-HPP). It provides a framework for the coordination of biology- and diseased-based research group contributions to the HPP as described in Aebersold et al. (2013) in JPR, 12, 23-27, Aebersold et al. (2014) in Proteomics (PDF) (highlights of B/D-HPP workshops in Yokohama), and Van Eyk et al. (2016) in JPR.

Several groups have begun to assemble prioritized lists of proteins relevant to several different diseases and biological systems and have made them publicly accessible, including popular protein lists for cardiovascular, cerebral, hepatic, renal, pulmonary, and intestinal systems in Lam MP et al. (2016) in JPR.

B/D-HPP Executive Committee (2020-2021)

  • Michal Bassani-Sternberg, Switzerland
  • Ferdinando Cerciello, Switzerland
  • Fernando Corrales, Spain (Past Chair)
  • Ileana Cristea, USA (Chair)
  • Eric Deutsch, USA
  • Maggie Lam, USA
  • Aleksandra Nita-Lazar, USA
  • Gil Omenn, USA (Advisory Member)
  • Nicki Packer, Australia (Co-chair)
  • Frank Schmidt, Qatar

Recent key publications

Publications can be found under each B/D-HPP team page listed below. 


The biology/disease-based HPP aims to expand our understanding of the human proteome with a focus on important biology research aspects and ongoing disease-focused research. Biology/Disease Human Proteome Project (B/D-HPP)

Many of the B/D groups were independent HUPO initiatives prior to the development of the HPP structure and some are newly formed.  There are three groups that continue to function as independent HUPO initiatives as well as under the B/D branch of the HPP.

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