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Biology & Disease-driven human proteome project (B/D-HPP)

Musculo Skeletal Immuno Peptidome Human Glycoproteomics Initiative Plasma

Mission of the B/D-HPP

One of the two main programs of the Human Proteome Project is the Biology/Disease-driven Human Proteome Project (B/D-HPP). It provides a framework for the coordination of biology- and diseased-based research group contributions to the HPP as described in Aebersold et al. (2013) in JPR, 12, 23-27, Aebersold et al. (2014) in Proteomics (PDF) (highlights of B/D-HPP workshops in Yokohama), and Van Eyk et al. (2016) in JPR.

The biology/disease-based HPP aims to expand our understanding of the human proteome with a focus on important biology research aspects and ongoing disease-focused research. Biology/Disease Human Proteome Project (B/D-HPP) This project seeks to identify and characterize the proteins encoded by the human genome, as well as to study the structure and function of the proteins and their interactions. It is hoped that understanding the human proteome will enable the development of new treatments for diseases. This project will also provide valuable insights into the molecular mechanisms of disease, as well as provide new avenues for drug discovery and development. Ultimately, the B/D-HPP will enable a better understanding of the human body and its complex processes. This knowledge can then be applied to develop new diagnostics, preventive strategies, and treatments for a wide variety of diseases. With the help of this project, we can make significant progress towards improving human health and well-being. Ultimately, this will lead to an improved quality of life for individuals and a healthier population. It could be a major step towards achieving universal health coverage and reducing health disparities.


Several groups have begun to assemble prioritized lists of proteins relevant to several different diseases and biological systems and have made them publicly accessible, including popular protein lists for cardiovascular, cerebral, hepatic, renal, pulmonary, and intestinal systems in Lam MP et al. (2016) in JPR.

Recent key publications

Publications can be found under each B/D-HPP team page. 

B/D-HPP Executive Committee

  • Bogdan Budnik, USA (Chair)
  • Nicki Packer, Australia (Co-chair)
  • Ferdinando Cerciello, Switzerland
  • Livia Rosa, Brazil (ECR)
  • Ed Nice, Australia (Advisory member)
  • Uwe Voelker, Germany
  • Francis O'Reilly, USA
  • Anthony Gramolini, Canada

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