One of the two main programs of the Human Proteome Project is the Biology/Disease-driven Human Proteome Project (B/D-HPP). It provides a framework for the coordination of biology- and diseased-based research group contributions to the HPP as described in Aebersold et al. (2013) in JPR, 12, 23-27, Aebersold et al. (2014) in Proteomics (PDF) (highlights of B/D-HPP workshops in Yokohama), and Van Eyk et al. (2016) in JPR.
Several groups have begun to assemble prioritized lists of proteins relevant to several different diseases and biological systems and have made them publicly accessible, including popular protein lists for cardiovascular, cerebral, hepatic, renal, pulmonary, and intestinal systems in Lam MP et al. (2016) in JPR.
Recent key publications:
Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems.
Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016
Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P.
J Proteome Res. 2016 Jul 19
Prioritizing Proteomics Assay Development for Clinical Translation
Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE.
J Am Coll Cardiol. 2015 Jul 14;66(2):202-4
Biology and Disease-Driven Groups of the HPP (B/D – HPP)
The biology/disease-based HPP aims to expand our understanding of the human proteome with a focus on important biology research aspects and ongoing disease-focused research. Biology/Disease Human Proteome Project (B/D-HPP)
Many of the B/D groups were independent HUPO initiatives prior to the development of the HPP structure and some are newly formed. There are three groups that continue to function as independent HUPO initiatives as well as under the B/D branch of the HPP.