Title: Postdoctoral Associate- Mass Spectometry

Company: Alkahest

Location: San Carlos, California United States

Summary: Alkahest is a clinical-stage biopharmaceutical company targeting neurodegenerative and age-related diseases with transformative therapies derived from a deep understanding of the plasma proteome in aging and disease. Uniquely positioned to enhance quality of life in aging, we are pioneering science that is rapidly being translated to the clinic. We offer a competitive compensation and benefits package, opportunities for career growth and development, and a work environment that is collaborative, collegial, and fun.

The mass spectrometry research group of Alkahest is seeking a postdoctoral scientist. Our lab develops and applies cutting-edge bottom-up quantitative proteomics strategies to discover novel biomarkers from human plasma. To further this goal, we are interested in characterizing post-translational modifications in plasma proteins in the context of aging and disease. We are looking for a highly motivated and driven postdoctoral scientist to:

• Develop innovative proteomics screens to quantify post-translational modifications in plasma proteins
• Work with other lab members anprod collaborators to interrogate and validate new biomarkers
• Play an active role in driving the direction of their own project, with the overall goal of publishing in high-profile journals

Requirements:

• PhD degree within the last 2 years from an accredited college/university in a field related to mass spectrometry, biochemistry, cell biology, molecular biology, biomedical research or chemical biology
• Experience with operating mass spectrometers and/or HPLCs
• Experience in performing at least one major form of quantitative DDA or DIA proteomics screen.
• Experience with other biochemical and/or molecular techniques is an advantage
• Ability to work collaboratively with excellent interpersonal, verbal and written communication skills
• Attention to detail and strong organizational skills

Desirable Criteria:

• Proven ability to operate and maintain Thermo Orbitrap LC/MS systems
• Experience with TMT-labelling and label-free DIA quantitative proteomics
• Strong background in plasma biology
• Competence with popular mass spectrometry software (ie. Proteome Discoverer, MaxQuant, Spectronaut, Masspike, etc)
• Ability to code in R and python to further analyze proteomics data

If interested, please apply via our Careers Page.

Link to full description.

Title: Assistant or Associate Professor at the Proteomics Bioinformatician Faculty

Company: Innovation Center on Single Cell ‘Omics & Precision Medicine and the Advanced Clinical BioSystems Research Institute, Cedars-Sinai Medical Center (CSMC)

Location: Los Angeles, USA

Summary: Applications are invited for a full-time Proteomics Bioinformatician Faculty position at the Assistant or Associate Professor level to join the Innovation Center on Single Cell ‘Omics & Precision Medicine and the Advanced Clinical BioSystems Research Institute, Cedars-Sinai Medical Center (CSMC). The Innovation Center is a new initiative launched at CSMC and is established to integrate our top researchers in genomics, transcriptomics, metabolomics epigenetics in order to enable fully collaborative, large scale efforts for precision molecular profiling at the single-cell level and high-throughput molecular screening in drug response and genomic perturbation platforms. We are seeking a computational faculty to join this initiative and collaboratively lead efforts in data integration and conversion of proteomic data to knowledge for application of precision science to the definition of individualized disease phenotype, diagnostics, and therapeutics.

The faculty Bioinformatic scientist is expected to build a collegial and collaborative research program that incorporates new strategies for leveraging of quantitative proteomics as well as other complex data sets in proteomics for clinical translational research that transcends traditional research boundaries in developing personalized diagnostics and novel individualize therapies. The faculty Bioinformatics Scientist will be expected to (i) conduct independent, extramurally funded research in their area of medicine, (ii) establish collaborations that amplify the work of other researchers who would benefit from bioinformatics approaches within the context of single cell and high throughput screening, (iii) teach in the graduate program and mentor trainees.

Applicants must have an MD, PhD, or equivalent degree in Computer Science, Mathematics, Data Science, Computational Biology, Bioinformatics or Biostatistics, with strong quantitative training, or other closely related field. Individual with strong wet lab with strong Bioinformatics will also be considered. The applicant will have 5 or more years of experience in a research environment (medical/biotechnology industry and/or post-doctoral experience), with background and work knowledge in algorithms, scientific computing, machine learning or other complex statistical methods. Experience in innovating as well as analyzing and annotating very large proteomic data sets both in exploratory and pipelines scenarios is required.

The successful candidate will need a track record of scientific leadership and collaboration, peer-reviewed research and grant funding commensurate with rank, a strong publication history, excellent interpersonal skills, and the ability to thrive in a multi-disciplinary environment. Faculty rank commensurate with experience and an attractive salary package with great career development opportunities and team development will be offered to the successful candidate.

Interested candidates should send their curriculum vitae, names and contact information for five references, and a cover letter describing their career goals and research experience to: Dr. Jennifer Van Eyk, Director, Advanced Clinical BioSystems Research Institute c/o: Academic.Recruiting@cshs.org

Title: Postdoctoral Research Fellow

Company: Vanderbilt University

Location: Nashville, Tennessee, United States

Summary: The laboratory of Jeff Spraggins in the Mass Spectrometry Research Center and Department of Cell & Developmental Biology at Vanderbilt University is looking for outstanding postdoctoral candidates that will join a team of graduate and post-graduate researchers to develop multimodal 2-D and 3-D imaging mass spectrometry. Multiple projects are available, including developing MALDI imaging instrumentation, spatially driven multi-omics, tissue processing and preparation methods, and computational data integration and mining tools. These projects involve constructing molecular atlases of human tissue and understanding the molecular drivers of host-pathogen interactions.

Post-doctoral candidates joining the Mass Spectrometry Research Center will have access to state-of-the-art instrumentation, including 9T and 15T Bruker Fourier transform ion cyclotron mass spectrometers with MALDI and ESI sources, two Bruker timsTOF ion mobility/Q-TOF mass spectrometers with MALDI and ESI capabilities, a Bruker Rapiflex MALDI tissuetyper, and a Thermo Orbitrap Elite mass spectrometer with a Spectroglyph transmission geometry source capable of 1 micron imaging. We also have high-performance LC-MS/MS instrumentation including a Thermo Orbitrap Fusion Tribrid mass spectrometer, a Bruker Impact II Q-TOF with a nanoElute LC system, and an Agilent AssayMAP Bravo liquid handler. Multimodal and microscopy-based imaging instrumentation include a GeoMX Digitial Spatial Profiler, a Zeiss Axio Observer Z1 inverted microscope integrated with an Akoya CODEX system, and a Zeiss Axio Scan Z1 brightfield and fluorescence slide scanner. The Mass Spectrometry Research Center also hosts a collection of commercial and state-of-the-art custom software for analysis of imaging, multiomics, and microscopy data.

Post-doctoral candidates will benefit from faculty with a diverse range of expertise including chemistry, biochemistry, engineering, computation, and biology. The Mass Spectrometry Research Center at Vanderbilt University is a leading institution for the development of imaging mass spectrometry and multimodal technologies providing a systems biology view of biological systems at cellular resolution.

Requirements: MALDI imaging, LC-MS, immunohistochemistry, and/or transcriptomics skills are required. Skills that are a plus, but not required, include instrumentation development, programming/scripting, bioinformatics, image processing and visualization, knowledge in pathology and infectious disease, ability to work simultaneously on multiple projects (including internal and external collaborations), and strong willingness to learn additional research skills if needed.

Contact: If interested please email Jeff Spraggins at jeff.spraggins@vanderbilt.edu

Title: Scientific Officer

Company: Northwestern Proteomics

Location: Chicago, IL

Summary: The Northwestern Proteomics invites applications for the position of Scientific Officer. This is a senior thought leader position that is responsible for implementing the strategic objectives under the guidance of director Neil L. Kelleher. Northwestern Proteomics is at the leading edge of technology for top-down and single cell proteomics, and proteoform mapping, and spearheads worldwide collaborations in developing the human proteoform atlas. This position requires a unique combination of scientific expertise and experience, organizational and communications capabilities, and interpersonal skills. It offers an opportunity to be at the forefront of the next great wave of chemical biology discovery, supported by a team of outstanding scientists and administrators. Applicants should submit a letter of application, curriculum vita, and three letters of reference to Dr. Sheila Judge (s-judge@northwestern.edu), Senior Director for Research, Education and Administration, Chemistry of Life Processes Institute; http://clp.northwestern.edu. Women and members of underrepresented groups are strongly encouraged to apply for this position.

Title: Postdoctoral Fellow - MS-based proteomics, cellular senescence, & aging biomarkers

Company: National Institute on Aging, NIH

Location: Baltimore, MD

Summary: The Translational Geroproteomics Unit (TGU) is seeking diverse, highly motivated, and enthusiastic postdoctoral fellows to tackle important questions in aging biology using proteomic approaches. This is a full-time and fully funded primary research fellowship for individuals interested in leveraging mass spectrometry-based proteomics to have a translational impact on age-related diseases linked to hallmarks of aging such as cellular senescence and loss of proteostasis. Postdoctoral fellows will be mentored by Dr. Nathan Basisty, and will have access to a highly interactive, resourceful, and dynamic scientific environment with state-of-the-art instrumentation and ample opportunities for training and career development.

The NIH and the TGU are dedicated to building a diverse community in its training and employment programs and are committed to creating and maintaining an environment that is welcoming, safe, accessible, and uplifting to ALL individuals. We encourage and welcome applications from individuals from underrepresented backgrounds.

Potential projects: We are looking for postdocs interested in working on various projects, including but not limited to:

• Discovery and validation of ‘proteoform’ (modified proteins and protein isoforms) biomarkers of aging and their relationship with the rate of aging, the development of age-related diseases as well as physical and cognitive disability in human cohort studies such as the BLSA, GESTALT, and InCHIANTI.
• Targeting and quantifying senescent cells and dissecting the functions of heterogeneous senescent cell populations via their surfaceomes (cell surface proteomes).
• Mass spectrometry method development, particularly the development and application of workflows involving data independent acquisition (DIA/SWATH), PTM identification/quantification, and/or protein turnover analysis.

Postdocs are encouraged to independently develop and drive the direction of their research projects, as well as establish new research directions.

Training and career development: Fellows will have access to hands-on training in multiple technologies and scientific techniques including mass spectrometry-based proteomics on several high-end instruments, analytical chemistry, cell culture, and mouse work. The NIA offers multiple career development opportunities for postdocs, including opportunities to apply for internal funding through the FARE (Fellows Award for Research Excellence) program, Nathan Shock travel awards, Interlaboratory Funding Proposals, Postdoctoral Fellowship Funding Awards, and the Independent Research Scholar (IRS) Program.

Postdocs are highly encouraged to attend conferences and scientific workshops for career development. Training also includes active participation in weekly multidisciplinary lab meetings, weekly Longitudinal Studies Section (LSS) Meetings, monthly Translational Gerontology Branch meetings, and professional development and research methods courses offered through the NIH Office of Intramural Training and Education (OITE). Fellows are also encouraged to take advantage of the NIH interest groups, particularly the Proteomics Interest Group and the NIA Molecular Biology Interest Group.

Postdocs will also have the opportunity to collaborate on projects with the Baltimore Longitudinal Study of Aging (BLSA), the longest running human aging study in the U.S., as well as other human cohorts (GESTALT, InCHIANTI).

Qualifications: The successful candidate must have a PhD, MD, or equivalent doctoral degree. We are looking for candidates with background and/or a strong interest in one or more of the following areas: mass spectrometry-based proteomics, characterization of PTMs, cell culture, or related fields who are passionate and self-motivated in research. Candidates with prior experience developing and performing mass spectrometry workflows, coding with R or Python, and experience with human or mouse aging models are especially encouraged to apply.

To Apply: Please email a (i) CV, (ii) cover letter detailing research interest, experience, and career goals, and (iii) three professional references to Nathan Basisty, PhD at nathan.basisty@nih.gov. Position open until filled.

Contact information: nathan.basisty@nih.gov; 
@nbasisty; https://www.linkedin.com/in/nbasisty/

Link to full description.

This position is subject to a background investigation.

The NIH is dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities. DHHS and NIH are Equal Opportunity Employers.