Position Title: Postdoc in Proteomics and Leukemia
Company: Lund University
Location: Lund, Sweden  

Overview:
An exciting opportunity for a postdoctoral fellow is available in the Proteomic Hematology group of Senior Lecturer Jenny Hansson at Lund Stem Cell Center within Lund University. We are seeking a highly motivated postdoc with a strong background in hematopoiesis or mass spectrometry-based proteomics to join the laboratory.

Background:

Infant leukemia arising during the first year of life is a blood cancer associated with very poor prognosis. New therapeutic options that are tailored to the biology of the disease are essential to improve patient outcomes. A promising avenue to exploit therapeutically is the interdependence of the leukemic cells and their local microenvironment (niche).

Your project:

This project aims to advance the understanding of the proteomic interplay between leukemic cells and their niche across fetal and infant life. The fellow will study the developmental leukemia niche and investigate the therapeutic efficacy of a disturbance of the interconnected leukemia-promoting protein networks.

The institute:

Lund is a European hub for research.

Lund University was founded in 1666 and is repeatedly ranked among the world’s top 100 universities. The University has around 46 000 students and more than 8 400 staff. As postdoc in the Proteomics Hematology group, you will be part of a stimulating scientific community within Lund Stem Cell Center, a strategic center of excellence in life science, with a strong international position in blood and stem cell research. Career development courses and workshops will be available to the postdoctoral fellow through the Lund Research School in Stem Cell Biology, and opportunities will be given to apply for own research grants. The postdoc will have access to state-of-the-art equipment, facilities, and infrastructure, including next-generation mass spectrometry instrumentation. We are looking for candidates to contribute to this dynamic and inclusive environment.

The following qualifications are required:

• Proven excellence in either hematopoiesis or mass spectrometry-based proteomics. Experience in both fields is an advantage.
• Excellent verbal and written communication skills in English.
• High willingness to learn new things.
• Good cooperative ability and ability to take initiatives.
• PhD degree within technical biology, analytical chemistry, molecular biology, biomedicine, cell biology, or similar.
• The PhD degree must not be older than 3 years.
• The applicant must not have been employed at Lund University in the past 2 years.

The following are advantageous (not required):

• -PhD in proteomics and/or hematopoiesis.
• Practical experience with preparation of biological samples for mass spectrometric analysis and/or practical experience with isolation and transplantation of hematopoietic stem and progenitor cells.
• Good theoretical knowledge in advanced mass spectrometry and/or practical experience with advanced flow cytometry.
• Experience with modern quantitative proteomic analysis and/or experience with cell culture of hematopoietic cells.
• Experience with analysis of large-scale proteomics data.
• Practical experience with Orbitrap MS and Dionex Ultimate 3000 nLC
• Experience of molecular biology approaches such as proximity labelling assays, immunoprecipitation, Lysosome Targeting Chimera (LYTAC) or other.

Written application, including reference number V2023/528, is to be sent via e-mail to jenny.hansson@med.lu.se and must include:

PhD diploma, CV, personal letter stating the reasons why the project suits the applicant (maximum one page), list of publications, and two references.

Close date: 23.04.2023

More information:

https://www.intramed.lu.se/forska/anslag-och-stipendier/stipendier-fran-fakulteten Reference V 2023/528

Jenny Hansson, Senior Lecturer, jenny.hansson@med.lu.se

Twitter: @HanssonLab

Lund Stem Cell Center: https://www.stemcellcenter.lu.se

Position Title: Senior Scientist / Principal Scientist, Chemical Biology/Chemoproteomics
Company: Dundad Therapeutics, Ltd
Location: Cambridge, UK

Overview: 
We are looking to hire a Chemical Biology/Chemoproteomics Senior / Principal Scientist to play a key part in future success of Dunad by developing and applying cutting-edge chemical biology and chemoproteomics methods with Dunad’s Claymor™ Platform – our proprietary approach to covalency and mono-valent targeted protein degradation – to accelerate our early stage pipeline. You will be responsible for designing experiments to take advantage of Dunad’s existing chemoproteomics platform as well as developing new chemical biology capabilities. You will support and strengthen the company's internal programmes as well as Dunad’s pharma collaborations. You will help us define and refine our internal target pipeline as well as provide essential support for our Drug Discovery programmes. Importantly, you will be a key part of a close-knit, patient-focused team of drug discovery scientists.

Key Responsibilities/Deliverables include:

• Contribute to the design and development of Dunad’s chemoproteomics platform and capabilities.
• Design and develop innovative chemical biology approaches, tailored to the Dunad Claymor platform, to deliver new targets and chemical starting points for drug discovery.
• Work with Dunad’s bioinformatics team to develop and apply world-class proteomics data analysis and machine learning / AI capabilities to accelerate quality target/hit-discovery.
• Work with our CRO partners and academic collaborators to develop new chemoproteomics and chemical biology capabilities for the Dunad Claymor platform – our proprietary approach to mono-valent targeted protein degradation.
• Communicate efficiently with all internal and external stakeholders and be a key member of the Drug Discovery project teams at Dunad.

Qualifications, Skills and Experience:

• PhD + >2 years’ experience in chemistry, chemical biology, chemoproteomics or a closely related subject.
• Deep experience in cutting edge chemical biology approaches for target identification, validation and hit finding.
• Experience with a variety of MS chemoproteomics methods. Experience with covalent drug discovery or protein degradation modalities a plus.
• Experience collaborating with diverse teams of drug discovery experts, with a track record of delivery.
• Ability to independently design experiments and present results as part of wider drug discovery team.
• Problem solver, team player with strong communication skills.

What you'll get in return:

The job title and compensation will be aligned with biotechnology industry practices, offering you a competitive salary, bonus, and equity. You will be a key member of the Drug Discovery team at a cutting-edge company that has rapid expansion plans!

• Link to Full Job Description
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• Contact Information

Position Title: Assistant or Associate Professor Proteomics & Tumor Immunology (0.8 – 1.0 FTE)
Company: Department of Pharmaceutical Sciences, Biomolecular Mass Spectrometry and Proteomics, Utrecht University
Location: Utrecht, Netherlands 

Overview: Within the Department of Pharmaceutical Sciences, we are looking for a new faculty member to join our Biomolecular Mass Spectrometry and Proteomics group. Our research programme is part of the renowned Utrecht Institute for Pharmaceutical Sciences (UIPS).

Your focus in this position will be on proteomics with applications in tumor immunology and cancer. As a mass spectrometry expert, you will pursue opportunities for proteomics research in areas related to antigen presentation, tumor micro-environments, secretomics, single cell and spatial proteomics, and systems and quantitative biology. In addition, you are skilled in analytical and computational method development and desire to further contributions in these areas.

You will strengthen the excellent international scientific profile of UIPS and its central mission of studying molecular mechanisms of disease. You will establish collaborations within UIPS, the Faculty of Science , the UMCU, the Princess Maxima Centre, the Hubrecht Institute, and with other national and international institutes, in particular in connection to the ONCODE-PACT programme.

You will participate in the organization and management activities related to UIPS research and education programs and strengthen the Biomolecular Mass Spectrometry and Proteomics group. You are enthusiastic to lead teaching activities at both BSc and MSc level and supervise research projects of Postdoctoral Researchers, PhD candidates and MSc students.

We are open to applicants at both junior and more matured level of their career stages. In addition to the experience you bring, it is essential that you make a positive contribution to our research group with your passion for research and teaching.

Qualifications:

We would like you to meet the following criteria:

A PhD in Pharmaceutical Sciences or a related field.

You have an internationally acknowledged research line with a strong publication and funding record.

You are an active player in international scientific communities.

Strong communication skills.

Supportive to create a collaborative, sustainable and inclusive work environment.

Link to Full Description:

https://www.uu.nl/en/organisation/working-at-utrecht-university/jobs/assistant-or-associate-professor-proteomics-tumor-immunology-08-10-fte

Position Title:  Research Specialist in Protein Science
Company: Roy J. Carver Biotechnology Center-Division of Proteomics at the University of Illinois, Urbana-Champaign
Location: Urbana, IL, USA

Overview:
The Research Specialist performs sample preparation, measurement, analytics, and provides assistance in the operation of the Protein Science Facility.

B.S. in Chemistry or an alternate life sciences major and one year of wet laboratory experience is required.

For full position announcement including full list of responsibilities, qualifications and application requirements, please visit https://go.illinois.edu/ResearchSpecialistProteinScience and apply by 6:00 pm (CST) on Wednesday, February 1, 2023.

The University of Illinois System is an equal opportunity employer, including but not limited to disability and/or veteran status, and complies with all applicable state and federal employment mandates. Please visit Required Employment Notices and Posters to view our non-discrimination statement and find additional information about required background checks, sexual harassment/misconduct disclosures, COVID-19 vaccination requirement, and employment eligibility review through E-Verify.

Applicants with disabilities are encouraged to apply and may request a reasonable accommodation under the Americans with Disabilities Act (2008) to complete the application and/or interview process. Requests may be submitted through the reasonable accommodations portal, or by contacting the Accessibility & Accommodations Division of the Office for Access and Equity at 217-333-0885, or by emailing accessibility@illinois.edu

Position Title:  Postdoctoral Scholar in Systems Virology
Company:  The Johnson Lab in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai
Location:  New York City, USA

The Johnson Lab in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai in New York City is seeking applicants for a postdoctoral position in the field of systems virology. The successful applicant will support projects integrating high-throughput genomics, proteomics, and CRISPR/Cas9 genetics technologies to understand signaling networks supporting viral infections, with the intention to identify novel targets for antiviral therapies. The Johnson lab has active, NIH-funded projects studying SARS-CoV-2, HIV-1, Ebola virus, yellow fever virus, and gammaherpesviruses. This position will primarily support a SARS-CoV-2 project.

Applicants should have substantial experience in most of the following molecular biology and virology approaches: mammalian cell culture, molecular cloning, genetic perturbations (i.e., siRNA/shRNA knockdown, CRISPR/Cas9 knockout, lentiviral cDNA transduction), virus propagation and quantification, flow cytometry, and immunofluorescence microscopy.

Applicants should have some experience or a strong interest in developing systems biology skill sets such as next-generation sequencing, mass spectrometry-based proteomics, and bioinformatics analyses.

Applicants must be detail-oriented, highly organized, and willing to work as part of a diverse team.

The Department of Microbiology is a world-class environment for training in virology. The department, chaired by Dr. Peter Palese, includes more than 20 independent virology and immunology laboratories that support greater than 100 students and postdoctoral fellows. Laboratories in the department have high-level expertise in a wide variety of viruses (influenza, SARS-CoV-2, hepatitis C virus, arboviruses, retroviruses, Nipah and Hendra viruses, herpesviruses, and others) and many aspects of host immune defense.

Mount Sinai offers postdoctoral scholars a competitive wage and benefits package and subsidized housing within walking distance to the laboratory.

To apply for this position, please send 3 pdf files to jeffrey.johnson@mssm.edu: (1) a cover letter, (2) a CV, and (3) the names and contact information for 3 professional references.

Position Title: Senior Proteomic Specialist
Company: Emory University
Location: Atlanta, GA, USA

SUMMARY OF POSITION:

We are presently seeking a highly motivated individual Scientist to join the Proteomic Research Group within the Center for Description: Neurodegenerative Diseases (CND) at Emory School of Medicine, Atlanta, GA. Responsibilities will include work on a variety of research projects in quantitative proteomics in collaboration with members of the Emory CND. The individual will be expected to implement new techniques for mass spectrometry analysis to identify and quantify proteins from complex mixtures such as cell lysates, human/mouse brain tissues and plasma samples. In addition, the candidate will provide LC-MS/MS analyses, design SOPs, maintain equipment and provide annual progress reports to faculty. Other duties will include developing close working relationship with faculty in the CND that will shape and maintain scientific collaborations and contribute to peer review publications and research grants. The Emory CND is fully equipped with 7 state of the art mass spectrometers for discovery and targeted proteomics analyses.

JOB DESCRIPTION:

• The Academic Research Scientist functions as a highly skilled contributor/researcher and has significant authorship on publications and advanced knowledge and expertise of laboratory and experimental platforms necessary to advance basic and/or translational research programs.
• Staff Scientists will have leadership responsibilities, and will oversee quality and training of other team members.
• Duties include designing, developing and conducting research experiments.
• Will have expert knowledge and skills specific to the related program and advanced knowledge of methods of analyzing data from experimental platforms.
• May assist in grant and other funding applications as necessary and appropriate, or with approval of the responsible faculty director, may have their own research projects and/or have full responsibilities for specific areas of a program.

• With approval of the leading Emory faculty member a Scientist may be the principal investigator on grant proposals. Performs other responsibilities as required.

MINIMUM QUALIFICATIONS:

• PhD or MD and five years of professional level experience OR Master's degree and fifteen years of professional level experience in a technical or research lab.
• Laboratory experience will be based on area of assignment.
• Internship experience or experience prior to attaining the qualifying degree is not considered eligible work experience for this job classification.
• NOTE: Applicants applying with a M.D. or equivalent degree must be eligible for a Georgia medical license to meet the minimum qualifications.

NOTE: Position tasks are generally required to be performed in-person at an Emory University location.

Link to full description:
https://staff-emory.icims.com/jobs/102720/scientist-%28ar%29-som/job?mobile=false&width=1140&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240

LinkedIn Profile link: https://www.linkedin.com/feed/update/urn:li:activity:6940736974651609088?updateEntityUrn=urn%3Ali%3Afs_feedUpdate%3A%28V2%2Curn%3Ali%3Aactivity%3A6940736974651609088%29

Contact information:
1)    Eddie Fox, email: ejfox2@emory.edu
2)    Nick Seyfried, email: nseyfri@emory.edu

Position Title: Postdoctoral Researcher – MS-based Proteomics – LINE-1 Retrotransposons
Company: The European Research Institute for the Biology of Ageing (ERIBA)
Location: Groningen, The Netherlands

European Research Institute for the Biology of Ageing at The University Medical Center Groningen

Website

Twitter: @macro_momo

Overview:

The European Research Institute for the Biology of Ageing (ERIBA) is a research institute at the University Medical Centre Groningen (UMCG). ERIBA aims to discover molecular mechanisms of ageing that can be used as targets to prevent or delay age-related diseases.

The Laboratory of Macromolecules and Interactomes at ERIBA is looking for an experienced postdoctoral researcher to develop mass spectrometry-based assays for proteomics and analytical biochemistry. The position is funded for 2 years, extensions possible provided financial support.

This ad is geared towards a PhD-level scientist (our preferred recruitment) – however, an MS degree-holder would be considered if they have sufficient experience and demonstrated ability to drive projects (semi-)independently.

Responsibilities:

The successful applicant will initiate new research projects that excite them, within the domains of interest of our lab. For this position, primary emphasis will be placed on interactomics and biomarker development with LINE-1 retrotransposons. The successful applicant will also be expected to collaborate with others in the lab to leverage MS-based proteomics in their projects. We focus mostly on quantitative affinity proteomics using bottom-up analyses, however new method development proposals that capitalize on our research infrastructure will be enthusiastically supported.

We have access to multiple MS instruments, but our primary instrument is a Thermo Exploris 480 (w/ BioPharma option and FAIMS) interfaced with an UltiMate 3000 nano HPLC system. We also have a 908 Devices ZipChip for CE-MS and a many other instruments for analytical biochemistry and proteomic assay development. We will prioritize applicants with excellent training in the operation of Thermo Orbitrap instruments. Prior experience with protein immunoprecipitation and/or scientific programming in R would be considered highly advantageous for applicants.

Qualifications:

Required
·       PhD in analytical (bio)chemistry or related (or MS as mentioned above)
·       Notable experience in protein mass spectrometry
·       Independent research attitude
·       Strong communication and writing skills
·       Organized and results-oriented team player
Appreciated
·       A track record in proteomics research
·       Competent scientific programmer for data analysis and data visualization
·       Competence with other protein-related analytical techniques

To be considered for this position, please email John LaCava – provide a CV and a brief (one paragraph) description of your motivation for this position. Information on the salary and benefits are detailed here: https://werkenbijumcg.nl/-/vacatures/researcher-in-biochemistry/proteomics/10419-02s0007nlp

If you are considered for the position, you will eventually be asked to provide contact details for 2-3 professional references and will make an official application through our web-based system (link above).

More information:
Prof. John LaCava, Group Leader, ERIBA;
Information about the host lab: http://www.macromolecule.fun
Information about ERIBA: https://eriba.umcg.nl

Position Title: Research Technician – Biochemistry / Proteomics
Company:  The European Research Institute for the Biology of Ageing (ERIBA)
Location: Groningen, The Netherlands

European Research Institute for the Biology of Ageing at The University Medical Center Groningen

Website
Twitter: @macro_momo

The European Research Institute for the Biology of Ageing (ERIBA) is a research institute at the University Medical Centre Groningen (UMCG). ERIBA aims to discover molecular mechanisms of ageing that can be used as targets to prevent or delay age-related diseases.

Overview:

The Laboratory of Macromolecules and Interactomes at ERIBA is looking for an experienced technician to develop mass photometry and mass spectrometry-based assays for proteomics and analytical biochemistry. The position is funded for 1 year, extensions possible provided financial support.

Responsibilities:

The core responsibilities of the position will be to conduct paired experiments using mass photometry (MP) and mass spectrometry (MS). We have a research and development collaboration with Refeyn Ltd (https://www.refeyn.com) – this is a new technology platform, so no prior experience is expected; you will receive on the job training by Refeyn’s applications specialists. Starting from that basis, you will develop applications assessing the properties of immunoprecipitated samples by MP and MS. Outside of that, the successful applicant will participate in occasional shared lab upkeep task and assist others on their projects. Prior experience with protein MS / proteomics and routine protein analysis (e.g., SDS-PAGE, western blotting, BCA/Bradford assays, etc.) will be a major advantage for applicants.

Qualifications:

Required
·       BSc or MSc in analytical (bio)chemistry or related
·       Independent research attitude
·       Strong communication and writing skills
·       Organized and results-oriented team player
Appreciated
·       Experience in protein mass spectrometry (esp. Thermo Orbitrap systems)
·       Competence with other protein-related analytical techniques
·       Competent scientific programmer for data analysis and data visualization

To be considered for this position, please email John LaCava – provide a CV and a brief (one paragraph) description of your motivation for this position. Information on the salary and benefits we can offer are detailed here: https://werkenbijumcg.nl/-/vacatures/research-technician-biochemistry-/-proteomics/10419-02s0007nkp

If you are considered for the position, you will eventually be asked to provide contact details for 2-3 professional references and will make an official application through our web-based system (link above).

More information:
Prof. John LaCava, Group Leader, ERIBA;
Information about the host lab: http://www.macromolecule.fun
Information about ERIBA: https://eriba.umcg.nl

Position Title: Proteomics Scientist
Company: BERG Health
Location: Framingham, MA, USA

BERG Health is seeking a highly motivated Proteomics Scientist who will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry and clinical medicine. This role will join a team responsible for biomarker and target discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer.

Essential Duties and Responsibilities:

• Spearhead technical analysis of post-translational modifications (phosphorylation, acetylation, ubiquitation, sumoylation etc.). Contribute to the assessment of chemoproteomic analysis for MOA of specific compounds under investigation.
• Identify the mechanism of action of drugs and drug-like molecules; developing and optimizing novel, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications.
• Collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
• Mentor research associates.
• Other duties as assigned

Requirements:

• Requires a Ph.D. degree in Biology, Biochemistry, Chemistry or Analytical Sciences with relevant postdoctoral experience and 3-5 years' experience with nanoLC-MSMS analysis using HR/HA mass spectrometry instruments.
• A strong background in state-of-the-art proteomics, more specifically post-translational modification analysis; some experience in cell biology, signaling and/or systems biology.
• Familiarity with high-throughput quantitative methodologies such as TMT® and Label-free approaches.
• Ability to apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds.
• Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
• Demonstrated ability to analyze, interpret and present data in a clear fashion.
• Solid scientific training/productivity as identified through high impact publications demonstrating creative thinking as well as innovative technical approaches.
• Experience with Thermo/Bruker instrumentation platforms is a plus.

Link to full description: https://www.berghealth.com/careers/

Twitter, Facebook and Linkedin account information (including handles and links): https://www.berghealth.com/

Contact information: Michael Kiebish (Michael.kiebish@berghealth.com) – hiring manager

Position Title: Proteomics Principal Scientist
Company: BERG Health
Location: Framingham, MA, USA

BERG Health is seeking a highly motivated Proteomics Principal Scientist who will work within the Omics group to develop and apply state-of-the-art proteomics technology to address compelling questions in biology, chemistry and clinical medicine. This role will join a team responsible for biomarker and target discovery/validation in multiple disease areas, including neurodegenerative diseases and cancer.

Essential Duties and Responsibilities:

• Drive research in quantitative analysis of protein expression and modifications (phosphorylation, acetylation, ubiquitination, neddylation, etc.) as well as characterizing the role of different enzymes (eg. kinases) induced by perturbation using functional and activity-based mass spectrometry approaches. Examine chemoproteomic approaches for MOA of specific compounds under investigation.
• Identify the mechanism of action of drugs and drug-like molecules; developing and optimizing novel, broadly enabling proteomic technologies including targeted, quantitative MS assay development for proteins and modifications.
• Advance BERG’s diagnostic protein QC pipeline to develop advanced methods for intact protein separation and MS analyses.
• Collaborate closely with analytical biochemistry, molecular biology, and computational research staff to design, plan, and perform experiments, collect data, and conduct data analysis.
• Mentor scientists and research associates.
• Other duties as assigned

Requirements:

• Requires a Ph.D. degree in Biology, Biochemistry, Chemistry or Analytical Sciences with relevant postdoctoral experience and 6-10 years' experience with nanoLC-MSMS analysis using HR/HA mass spectrometry instruments.
• A strong background in state-of-the-art proteomics, more specifically post-translational modification analysis; some experience in cell biology, signaling and/or systems biology.
• Familiarity with high-throughput quantitative methodologies such as TMT® and Label-free approaches.
• Ability to apply and/or develop affinity/activity-based proteomic probes to profile the functional state of enzyme targets in native biological systems and assess the selectivity of compounds.
• Ability to work with an interdisciplinary team of biologists, chemists, and computational scientists to deeply characterize and understand the proteomes of cells, biofluids, and tissues.
• Demonstrated ability to analyze, interpret and present data in a clear fashion.
• Solid scientific training/productivity as identified through high impact publications demonstrating creative thinking as well as innovative technical approaches.
• Experience with Thermo/Bruker instrumentation platforms is a plus.

Link to full description: https://www.berghealth.com/careers/

Twitter, Facebook and Linkedin account information (including handles and links): https://www.berghealth.com/

Contact information: Michael Kiebish (Michael.kiebish@berghealth.com) – hiring manager