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Position title: Postdoc in Advanced Proteomics applied to Erythropoiesis
Company: Lund University
Location: Lund, Sweden

Summary of position:
An exciting opportunity for a Postdoctoral Fellow is available immediately in the Proteomic Hematology group of Dr. Jenny Hansson at the Division of Molecular Hematology of the Lund Stem Cell Center, Lund University, Sweden. The Lund Stem Cell Center is a strategic center of excellence in life science, with a strong international position in the area of blood stem cell biology. We are seeking a highly motivated and ambitious postdoctoral fellow with a strong background in mass spectrometry-based proteomics to join a cross-disciplinary research project together with the research groups of Martin L. Olsson (MD, PhD, Prof.), Johan Flygare (MD, PhD) and Kenichi Miharada (PhD).

Description
The postdoctoral fellow will use cutting-edge mass-spectrometry based proteomics approaches to identify the regulators active in the erythropoietic niches. This includes the implementation and application of innovative sensitive mass spectrometry approaches for analysis of few primary cells obtained by micromanipulation (proximity-based single cell approach) and FACS. The postdoctoral fellow will be a critical part of a team working to establish novel concepts for how and where red blood cell production is controlled, ultimately providing promising targets for conceptually new pharmaceutical approaches to treat anemia, one of the most common medical conditions globally.

Qualifications required
Candidates are expected to have a strong background in mass spectrometry-based proteomics and knowledge in quantitative proteomics. Experience with both data-dependent and data-independent acquisition approaches is desirable but not essential. Knowledge in cell biology, especially hematopoiesis and erythropoiesis, is an advantage. Candidates must be highly motivated to pursue postdoctoral studies within proteomics methods development as well as to apply these methods to answer complex biological questions. Abilities to work independently as well as part of a team are essential. Excellent verbal and written communication skills in English are required for consideration. PhD degree should not be more than three years old at the last day of applying.

Application
Application stating the reference number V 2019/357 and containing a personal letter, CV including list of publications and names and contact information of at least two reference persons, should be sent to: Jenny.Hansson@med.lu.se.

Application deadline: 2019-09-05.

Link to full description: https://academicpositions.com/ad/lund-university/2019/postdoc-advanced-proteomics-applied-to-erythropoiesis/131676

Contact information: jenny.hansson@med.lu.se

Expression of Interest

Postdoctoral Research Fellow, Mass spectrometry-based proteomics

The Signalling Network Laboratory in the Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Australia aims to identify novel therapeutic targets and biomarkers for particular poor prognosis human cancers, including triple negative breast cancer, prostate and gastric cancer, through an integrated strategy that combines mass spectrometry-based proteomics with bioinformatics, computational biology and functional genomics.

Expressions of Interest are invited for a Postdoctoral Research Fellow position that will utilize mass spectrometry-based phosphoproteomic and kinomic profiling workflows and associated bioinformatic approaches to characterize cancer signalling networks, with the goal of identifying novel therapeutic targets and biomarkers. It will involve use of established workflows, as well as development of novel ones for interrogation of non-canonical phosphorylation events, and analysis of patient specimens. The fellow will also contribute to the functional characterization of lead candidates emanating from these studies.

Established expertise in mass spectrometry-based (phospho)proteomics is essential, with the ability to analyse large datasets using appropriate bioinformatics techniques desirable. Knowledge and experience in cell biology and signalling is also desirable.

For more information contact Professor Roger Daly, roger.daly@monash.edu

The Monash Biomedicine Discovery Institute (BDI) is one of the largest and most dynamic biomedical research and teaching environments in Australia. The Institute and its cognate Departments of Anatomy and Developmental Biology, Biochemistry and Molecular Biology, Microbiology, Pharmacology and Physiology comprise over 120 research groups. The BDI works closely with clinical and drug development precincts at Monash and has several major industry partnerships to facilitate the translation of their research. For more information about the BDI please visit their website at www.monash.edu.au/discovery-institute.

NIH is recruiting a highly motivated Postdoctoral Research Fellow to study the protein signaling mechanisms in the cellular networks regulating inflammation and innate immunity.

Their research focuses on understanding the changes that occur in the cell proteome in response to exogenous factors such as pathogen-derived molecules, cytokines, and chemokines, which alter the differentiation state of cells in the immune system or whose production characterizes specific disease states. They are especially interested in large-scale absolute quantitative measurements of immune cell signaling cascade components and in the characterization of post-translational modification (PTM) dynamics on a global scale, protein-protein interactions and their implications in the inflammatory process initiated by the Toll-like receptors and the inflammasome, and the cellular processes that follow the encounter with pathogens, commensals, and tissue damage. NIH aims to develop mechanistic computational models that can be used to predict the behavior of this complex biological system and help explain the basis for physiological and pathological responses to infection or vaccination or to design new therapies or vaccines.

The position offers a vibrant and highly interactive setting in the NIH Intramural Research Program, a new state-of-the-art research lab, access to outstanding resources and technology platforms, strong computational support, and a friendly, collaborative and interdisciplinary group of colleagues in both the clinical and basic sciences.

Candidates should have a recent (less than 5 years) PhD (preferably in biochemistry or molecular immunology) and/or MD degree. Prior experience in proteomics is highly desirable; formal training in systems biology is encouraged. Knowledge of cell biology, protein chemistry, flow cytometry and big data analysis methods as well as ability to work collaboratively would be an asset.

The successful applicant will join the laboratory of Dr. Aleksandra Nita-Lazar, the Functional Cellular Networks Section within the Laboratory of Immune System Biology of the National Institute of Allergy and Infectious Diseases.

Information about Dr. Nita-Lazar and her laboratory can be found here: https://www.niaid.nih.gov/research/aleksandra-nita-lazar-phd

Applicants should contact Dr. Nita-Lazar directly at nitalazarau@niaid.nih.gov submitting a cover letter, curriculum vitae, and contact information for three references. To ensure full consideration, the application materials must be received by August 1, 2019, but applications will be accepted until the position is filled.