Research Fellow – Mancias Laboratory

Company: Dana-Farber Cancer Institute

Location: Boston, MA

Full Time

The laboratories of Joseph Mancias, M.D., Ph.D. at the Dana-Farber Cancer Institute and Steven Gygi, Ph.D. at Harvard Medical School in Boston, MA are inviting applications for a co-mentored funded postdoctoral researcher position to begin as early as January 2022.

The Post-doctoral fellow will be part of a rich intellectual and collaborative environment and will have access to state-of-the-art facilities within the laboratories, the Dana-Farber Cancer Institute, Harvard Medical School, and other top academic institutions across the Boston Area. Importantly, the Mancias Lab is part of a Pancreatic Cancer Research Collective, the Hale Family Pancreatic Cancer Research Center at Dana-Farber that brings together investigators from a wide variety of backgrounds for collaborative projects on pancreatic cancer.

The Mancias Lab studies critical aspects of the biology of pancreatic cancer to develop novel therapeutic approaches. We apply mass spectrometry-based quantitative proteomic technologies to address these questions (e.g. Mancias et al., Nature 2014; Mancias et al., eLife 2015; Santana-Codina et al., Haematologica 2019; Santana-Codina et al., Cell Reports 2020). The Gygi Lab is interested in developing and applying new technologies in the fields of mass spectrometry and proteomics (Huttlin et al. Cell 2021, Kuljanin et al. Nature Biotechnology 2021, Nusinow et al. Cell 2020). Prior post-doctoral fellows in this co-mentored position have had productive experiences (e.g. Kuljanin et al. Nature Biotechnology 2021, Banh et al. Cell 2020).

Requirements:

• Leading and collaborating on studies in and between the Mancias and Gygi Labs.
• Maintain and operate a state-of-the art mass spectrometer
• Designing and executing experiments.
• Conducting data analysis and interpreting results.
• Maintaining accurate records, writing reports, and preparing and giving presentations.
• Contributing to the overall laboratory safety, organization and productivity.
• Generating impactful peer-reviewed research articles.

Qualifications:

• The candidate should have recently received a Ph.D. focused on proteomics.
• A strong background in mass spectrometry.
• A background of scientific accomplishment including at least one first author peer-reviewed publication.
• Evidence of oral and written communication skills in English.

A successful candidate will be highly motivated, independent yet willing to collaborate with other team members and eager to develop and pursue a novel research program.

For more information and to apply, please visit:
https://careers.dana-farber.org/research_fellow_mancias_laboratory

About Dana-Farber:
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

Title: Postdoc in Clinical Proteomics

Company: Newcastle University

Location: Newcastle upon Tyne, UK

Summary: Applications are invited for a post-doctoral position to work in the group of Prof Matthias Trost on clinical proteomics in mitochondrial disease. In collaboration with local clinicians of the Wellcome Centre for Mitochondrial Research we will apply state-of-the-art DIA proteomics approaches to identify molecular pathways affected by disease.

We seek a talented and enthusiastic post-doctoral scientist with a background in proteomics and mass spectrometry. You will have a good academic track record and have published at least one first authored paper in an international, peer reviewed journal. You will ideally have hands-on mass spectrometry experience and are an expert in proteomics. Knowledge in R programming language, proteomics data analysis pipelines as well as disease models would be advantageous.

Link to full job description. 

Company: Whitehead Institute for Biomedical Research

Location: Cambridge, Massachusetts

Summary: The Quantitative Proteomics Facility Manager/Director will coordinate the development and implementation of cutting-edge mass spectrometry approaches to address diverse questions in biomedical research. They will collaborate with and advise scientists at Whitehead and the broader community on the effective application of innovative methods in quantitative proteomics to advance their research. To this end, they will oversee all core facility operations including acquisition and maintenance of equipment and affiliated software and peripherals, development of protocols, training of facility users, safety, inventory and ordering of supplies, data management, and oversight of facility staff. Billing, accounting, and other administrative responsibilities will receive the support of the Administrative Lab Manager for Core Facilities. All duties will be performed in accordance with Whitehead Institute’s behavioral standards, mission, values, and vision.

Link to full description

Contact Information:

Sharon Bright

Human Resources and DEI Specialist

Whitehead Institute for Biomedical Research

455 Main Street, Cambridge MA 02142

Title: Bioinformatics Technology Manager

Company: Australian Proteome Analysis Facility

Location: Macquarie University, New South Wales, Australia

Summary: We are seeking an expert who is ready to join our team as Technology Manager – Bioinformatics. This role will lead the Bioinformatics team at the Australian Proteome Analysis Facility (APAF) at Macquarie University. Reporting to the APAF Manager you will:

• Contribute to the development and delivery of APAF's strategy, taking a lead role within the specialist stream of Bioinformatics
• Work with clients and APAF staff to develop and implement optimal Bioinformatics solutions and analysis ensuring that they operate in a robust, accurate, cost effective and timely manner
• Manage and contribute expert advice for the day to day operations, projects, initiatives and resourcing for Bioinformatics, ensuring a highly professional and effective service is provided to clients, team members, users and stakeholders
• Maintain knowledge, expertise and currency in sector trends and developments within Bioinformatics, working with stakeholders and the team to incorporate best practice and build protocols, capability and services.
• Establish, implement, document and test informatics methods, tools and capabilities
• Carry out validation and verification of tools and analyses to be used in NATA-accredited testing.
• Manage, coach and develop a high performing team
• Contribute to business development and service improvement initiatives to grow and expand APAF bioinformatics capabilities

Contact information:
Belinda Schiller, APAF facility manager
belinda.schiller@mq.edu.au

Link to full description.

Title: Research Associate and a Postdoctoral Fellow

Company: Smidt Heart Institute - Karlstaedt Lab

Location: Los Angeles, USA

Summary: Karlstaedt Lab at Cedars-Sinai Medical Center is recruiting a research associate and a Postdoctoral Fellow to work in the field of cardio-oncology. Candidates will join an interdisciplinary and highly collaborative team of scientists and physician-scientists within the Smidt Heart Institute and the Advanced Clinical Research Institute directed by Dr. Jennifer Van Eyk. Our Research Associates and Postdoctoral Fellows will be working within a dynamic program at the interface of cardiology and oncology to study metabolic interactions between cancer cells and the heart. Projects include murine cancer and heart failure models, ex vivo working heart perfusions, plasma profiling of patient samples, and stable isotope tracer analysis combined with metabolic flux analysis to study the dynamic range of metabolism in disease models (see lab website: https://karlstaedtlab.github.io/cardionet/). For more details on Postdoctoral Fellowships, please contact Dr. Anja Karlstaedt (anja.karlstaedt@csmc.edu).

Link to full description. 

Title: Postdoctoral Researcher

Company: Maria Robles Lab, Ludwig Maximilian University

Location: Munich, Germany

Summary: We are looking for a motivated and talented postdoctoral research with strong background in proteomics and/or bioinformatics to join an EU-funded multidisciplinary project “ REVEAL”. This consortium comprises innovative microscopy instrumentation, machine learning and multi-omics analysis of cancer cells in 2D and 3D with the final aim to understand the cellular origin hallmarks of this disease.

Please email, before January 31, 2022, a letter of interest highlighting your fit to this position and a detailed CV with 2-3 references to Maria Robles: crobles@med.lmu.de. 

Link to full description.

Title: Director of Mass Spectrometry

Company: Department of Cell and Molecular Physiology, Loyola University Chicago

Location: Illinois, Chicago

Summary: The Department of Cell and Molecular Physiology at Loyola University Chicago, Stritch School of Medicine (SSOM) seeks applicants for a full-time Lab Director/Instructor.

We are seeking enthusiastic applicants who enjoy working with graduate students to help implement the curriculum and lead the Mass Spectrometry laboratory for the brand-new Master of Science in Clinical and Applied Spectrometry (MS CAMS) program. Qualified candidates with a master’s degree or higher and at least two years of experience with Mass Spectrometry instruments are encouraged to apply.

The Lab Director’s duties and responsibilities include:

• Implement and refine curriculum for master’s students including hands-on laboratory training, supervision and assessments
• Procure and prepare samples for students to use
• Run mass spectrometry instruments
• Analyze and interpret mass spectrometry data
• Provide general lab maintenance including inventory, cleaning, safety and compliance, etc.
• Assist in managing mass spectrometry lab technician staff

Qualifications/skills:

• Proficiency with software used in research labs and willingness to learn new programs as necessary
• Minimum qualifications: Master’s degree or higher and two years’ experience with mass spectrometry instrumentation
• Preferred: Experience training students or technicians in a lab

The SSOM is undergoing rapid growth in all of its basic departments. Laboratory space will be in the state-of-the-art Center for Translational Research and Education (www.luc.edu/ctre). Review of applications will commence immediately, and applications will be accepted until the position is filled.

The Department of Cell and Molecular Physiology values and is committed to fostering a culture of equal opportunity for all persons. We strongly encourage individuals identifying as members of under-represented groups and women to apply. Loyola University Chicago is an Equal Opportunity/Affirmative Action employer with a strong commitment to hiring for our mission and diversifying our faculty.

Link to full description. 

Title: Postdoctoral Associate- Mass Spectometry

Company: Alkahest

Location: San Carlos, California United States

Summary: Alkahest is a clinical-stage biopharmaceutical company targeting neurodegenerative and age-related diseases with transformative therapies derived from a deep understanding of the plasma proteome in aging and disease. Uniquely positioned to enhance quality of life in aging, we are pioneering science that is rapidly being translated to the clinic. We offer a competitive compensation and benefits package, opportunities for career growth and development, and a work environment that is collaborative, collegial, and fun.

The mass spectrometry research group of Alkahest is seeking a postdoctoral scientist. Our lab develops and applies cutting-edge bottom-up quantitative proteomics strategies to discover novel biomarkers from human plasma. To further this goal, we are interested in characterizing post-translational modifications in plasma proteins in the context of aging and disease. We are looking for a highly motivated and driven postdoctoral scientist to:

• Develop innovative proteomics screens to quantify post-translational modifications in plasma proteins
• Work with other lab members anprod collaborators to interrogate and validate new biomarkers
• Play an active role in driving the direction of their own project, with the overall goal of publishing in high-profile journals

Requirements:

• PhD degree within the last 2 years from an accredited college/university in a field related to mass spectrometry, biochemistry, cell biology, molecular biology, biomedical research or chemical biology
• Experience with operating mass spectrometers and/or HPLCs
• Experience in performing at least one major form of quantitative DDA or DIA proteomics screen.
• Experience with other biochemical and/or molecular techniques is an advantage
• Ability to work collaboratively with excellent interpersonal, verbal and written communication skills
• Attention to detail and strong organizational skills

Desirable Criteria:

• Proven ability to operate and maintain Thermo Orbitrap LC/MS systems
• Experience with TMT-labelling and label-free DIA quantitative proteomics
• Strong background in plasma biology
• Competence with popular mass spectrometry software (ie. Proteome Discoverer, MaxQuant, Spectronaut, Masspike, etc)
• Ability to code in R and python to further analyze proteomics data

If interested, please apply via our Careers Page.

Link to full description.