The mission of the C-HPP
The Human Proteome Project (HPP) of the Human Proteome Organization (HUPO) aims to find high-stringency evidence for all proteins encoded by the human genome, the major splice forms of each protein, mature N- and C-termini, and their major protein post-translational modifications (PTMs). Indeed, one cannot do the best biology and/or medical research without a complete understanding of the parts of the human proteome. Conversely, the international C-HPP teams need the input of biology/disease (B/D) teams to understand the biological context of the parts list. It is a question of focus. A focus on the parts list promotes a measurement- and detail-focused analytical mindset, while a focus on the biological context is focused on outcomes and may ignore individual parts in the context of the overall picture. In conclusion, both mindsets are indivisible parts of the larger HPP initiative.
Questions and Answers on the C-HPP and Missing Proteins: Q & A
Journal of Proteome Research Virtual issue Celebrates 10 Years of the HPP and C-HPP (October 2020)
2020 C-HPP Executive Committee (EC)
Chair: Christopher M. Overall, Canada (to December 31, 2021)
Co-Chair: Lydie Lane, Switzerland (to December 31, 2023)
Co-Chair: Young-Ki Paik, Korea (to December 31, 2021)
Secretary General: Peter Horvatovich, The Netherlands (to December 31, 2022)
Member-at-Large: Pengyuan Yang, China (to December 31, 2021)
Member-at-Large: Fernando Corrales, Spain (to December 31, 2022)
Member-at-Large: Gilberto Domont, Brazil (to December 31, 2021)
The C-HPP Executive and Russian C-HPP Chromosome 18 Team Local
Organising Committees regret the necessity to cancel the 23rd C-HPP
Workshop in Saint Petersburg, Russia due to the pandemic of the
SARS-CoV-2 (2019-2020) virus leading to COVID-19 disease. Please check
back here periodically for updates on the 23rd C-HPP Workshop.
analogy to the term “dark proteins” coined to represent structurally
uncharacterized regions, C-HPP investigators have recently adopted the
term “dark proteome” to collectively refer to those proteins for which
we have insufficient
on either protein expression, structure, function, or all of these:
They include, for example, MPs (PE2−4), PE5, uPE1 proteins, and any
potential proteins translated from smORF or lncRNAs. When focused on
uPE1 proteins, there are nearly 2,000 proteins which have no functional
information (Paik et al., 2018, JPR, DOI:10.1021/acs.jproteome.8b00383).
March 1, 2018, HUPO C-HPP announced launching the neXt-CP50 where CP
stands for “characterization of proteins”. This pilot project aims to
characterize function of 50 uPE1 proteins during ~3 years (2018-2021).
This challenge is to test the feasibility of the functional
characterization of large numbers of dark proteins, 2000 at present the
15 teams are focusing on specific tractable targets that can be
the C-HPP consortium international teams, 15 from 12 countries joined
this project: Chr 2 (Switzerland), Chr 3 (Japan), Chr 4 (Taiwan), Chr 9,
11, 13 (Korea), Chr 10, Chr 14 (France), Chr 15 (Brazil), Chr 16
(Spain), Chr 17 (USA), Chr 18 (Russia), Chr 19 (Mexico), Chr 20 (China),
and Chr Y (Iran).
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