The Human Cancer Proteome Project (Cancer-HPP) is an international initiative organized by HUPO whose key objective is to decipher the human cancer proteome through a coordinated effort by cancer proteome researchers around the world. The ultimate goal is to map the entire human cancer proteome to disclose tumor biology and drive improved diagnostics, treatment and management of cancer which is one of the leading causes of death worldwide.

Aims:

• Characterize proteomes, proteoforms and protein networks from different cancers and matched non-cancers through coordinated efforts of specimen collection and data acquisition.
  
• Identify cancer-specific proteins, proteoforms, or protein networks by comparison of multiple cancer types through data deposition, sharing, and data analysis.
  
• Determine the protein-specific or protein-isoform-specific changes of cancer through the correlation of genomic and proteomic data through the comparison of the existing genomic data or the genomic data collected from each specimen.
  
• Develop targeted assays to measure protein- or proteoform-specific changes for each tumor type to support the analysis of complex biological networks or clinical specimens underlying different disease processes.
  
• Disseminate assays to the scientific community to apply the targeted assays to their specimens to verify the changes observed in the discovery phase.
  
• Validate the proteins, proteoforms, or protein network changes in independent larger cohorts.
  
• Identify unmet clinical needs.
  
• Collaborate with the Pathology Pillar to advance Precision/Personalised Medicine.
  
• Promote the Cancer BD-HPP to the non-HUPO community.
  
• Support the HPP Grand Challenge.