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Food and Nutrition Initiative


Mission

The central role of food proteins in nutritional science is indisputable, the well known affirmation that ‘we are what we eat’ and that food can be our medicine is not just philosophy but a sustainable strategy to effectively tackle the large increase on non-communicable diseases (NCDs). In fact, it is clear that food, after ingestion, is transformed releasing proteins that our body uses in a complex direct relationship with the microbiota. Investigating the proteome of a given food provides the fundamental knowledge to understand this transformation process. Furthermore, every nutritional functional process involves a huge number of proteins that are expressed at different levels, from cell to whole organism. Moreover, the global composition of diet, from microbiome to nutrient, including life style, can affect every step from gene expression to protein synthesis until degradation, leading to profound modulation of metabolic functions. Proteomics can help the development of a novel sustainable personalized medicine through nutritional intervention. These studies will play an important role in solving major nutrition problems in humans and animals, including obesity, metabolic and cardiovascular disease, cancer, ageing, allergy and fetal health and development. Profiling food, microbiome, and biomarkers of nutritional status from a proteomics point of view will potentially lead to a new pillar of personalized medicine. This includes a special focus on food safety, security and quality issues, providing new insights and technologies to grant safety, from microbiome and consortia, detection of animal species in the food, identification of food allergens to food authenticity.

Current lines of work:

  • Allergies and allergens
  • Nutriproteomics
  • Food safety
  • Food borne disease
  • Microbiota
  • AMR
  • Animal health (zoonoses)

Papers:

MALDI-TOF MS Approach for Mammalian, Human, and Formula Milks' Profiling. Di Francesco L, Di Girolamo F, Mennini M, Masotti A, Salvatori G, Rigon G, Signore F, Pietrantoni E, Scapaticci M, Lante I, Goffredo BM, Mazzina O, Elbousify AI, Roncada P, Dotta A, Fiocchi A, Putignani L.Nutrients. 2018 Sep 5;10(9). pii: E1238. doi: 10.3390/nu10091238

Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients. D'Auria E, Mameli C, Piras C, Cococcioni L, Urbani A, Zuccotti GV, Roncada P.J Proteomics. 2018 Sep 30;188:173-180. doi: 10.1016/j.jprot.2018.01.018.

Variety-specific nutrient acquisition and dehydration-induced proteomic landscape of grasspea (Lathyrus sativus L.). Rathi D, Pareek A, Gayali S, Chakraborty S, Chakraborty N. J Proteomics. 2018 Jul 15;183:45-57. doi: 10.1016/j.jprot.2018.05.013

Integrative network analyses of wilt transcriptome in chickpea reveal genotype dependent regulatory hubs in immunity and susceptibility. Ashraf N, Basu S, Narula K, Ghosh S, Tayal R, Gangisetty N, Biswas S, Aggarwal PR, Chakraborty N, Chakraborty S. Sci Rep. 2018 Apr 25;8(1):6528. doi: 10.1038/s41598-018-19919-5.

iMetaLab 1.0: a web platform for metaproteomics data analysis. Liao B, Ning Z, Cheng K, Zhang X, Li L, Mayne J, Figeys D. Bioinformatics. 2018 Nov 15;34(22):3954-3956. doi: 10.1093/bioinformatics/bty466.

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function. Mayne J, Ooi TC, Tepliakova L, Seebun D, Walker K, Mohottalage D, Ning Z, Abujrad H, Mbikay M, Wassef H, Chrétien M, Figeys D. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3486-3495. doi: 10.1210/jc.2018-00777.

Feta cheese proteins: Manifesting the identity of Greece׳s National Treasure. Anagnostopoulos AK, Tsangaris GT. Data Brief. 2018 Jun 28;19:2037-2040. doi: 10.1016/j.dib.2018.06.084

Foodomics - Novel insights in food and nutrition domains. Ferranti P, Roncada P, Scaloni A. J Proteomics. 2016 Sep 16;147:1-2. doi: 10.1016/j.jprot.2016.07.016
                         
Proteomics in food: Quality, safety, microbes, and allergens. Piras C, Roncada P, Rodrigues PM, Bonizzi L, Soggiu A.Proteomics. 2016 Mar;16(5):799-815. doi: 10.1002/pmic.20150036 

Links to other HPP groups:

Mitochondria.

Past events: 

  • HUPO 2015 Workshop – Proteomics in Food and Nutrition (read workshop report).
  • Dissemination in FAAM European Congress in Rome, October
  • Dissemination in IMEKO FOODS- metrology promoting objective and measurable Food Quality and Safety, Benevento, IT, October 2016
  • Organization of a session in Dublin 2017 EuPA /HUPO- Food and nutrition proteomics: focus on microbiota (interaction with Daniel Figeys- cHPP)

    Future meetings and activities:

    • European Proteomics Association- Proteomic Forum- MARCH 2019. Targeting Word Microbiota Congress Oct 2019 Paris 9–12 November 2019 | IN-Kalyani India | EMBO Symposium Italian Proteomics Association/Hellenic Proteomics Society meeting, Calabria, Italy, 2019 25-27 June


    Leadership:

    Paola Roncada, Chair | University “ Magna Græcia” of Catanzaro Department of Health Sciences, Italy
    Daniel Figeys, Co-Chair | University of Ottawa, Canada
    Subhra Chackraborty, Co-Chair
     | National Institute of Plant Genome Research, India

    For re information or participation opportunities please contact office(at)hupo.org.




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