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HUMAN GLYCOPROTEOMICS INITIATIVE


Leadership and Team members

Chair:


Morten Thaysen-Andersen, PhD

Macquarie University, Sydney, Australia



Co-Chairs:



Daniel Kolarich, PhD

Griffith University, Gold Coast, Australia




Nicolle H Packer, PhD

Macquarie University, Sydney, Australia




Early Career Researchers:


Rebeca Kawahara, PhD

Macquarie University, Sydney, Australia



Tiago Oliveira, PhD

Griffith University, Gold Coast, Australia


1st HGI Study (2017-2021)


Read more...


Our overall aim is to help the community to create the toolboxes required to address unexplored glycobiology-focused fundamental and applied research questions in human health and disease.

The Human Glycoproteomics Initiative (HGI) was established in 2017 by Distinguished Prof Nicki Packer and Dr Morten Thaysen-Andersen (both Macquarie University, Sydney, Australia). The HGI evolved from the Human Glyco/Proteomics Initiative (HGPI) (2004-2016) headed by Prof N. Taniguchi and Dr H. Narimatsu. A/Prof Daniel Kolarich (Institute for Glycomics, Griffith University, Gold Coast, Australia) joined the HGI leadership team in 2021.

The HGI aims to increase the understanding of the functional significance of the extensive post-translational modification of proteins by glycans. This can only be achieved when the proteomics community has well integrated analytical and informatics tools available to more easily enable the determination of site-, protein-, cell- and tissue-specific glycoform structural heterogeneity in complex biological systems. While other -omics disciplines including genomics and proteomics have matured over past decades, glycoproteomics remains comparatively under-developed limiting our ability to gain insight into the immensely complex, dynamic and functional glycoproteome. Glycoproteomics may therefore be seen as one of the missing pieces of the -omics jigsaw puzzle.


The HGI is a project/study-centric initiative; our modus operandi is to assemble relevant experts and field-leaders to complete specific studies of particular interest to the community. We seek to progress the field by influencing reporting guidelines (e.g. MIRAGE), nomenclature (SNFG) and experimental recommendations, and by connecting with and bridging into neighbouring disciplines. We aim to promote and draw more attention to our emerging discipline, highlight exciting opportunities and key challenges in the field, and unite like-minded scientists not least to bridge researchers in proteomics and glycomics through dialogue, comparative studies, and open sharing of data, tools and ideas.

The HGI also connects with other Biology/Disease-Human Proteome Project (B/D-HPP) activities in HUPO and permits the exchange of information of mutual interest. The data and information produced by the HGI will be shared widely with the community and will be made available for public, industry, academic research and teaching purposes.


Other Community Initiatives in the Glycosciences:

The Human Glycome Project

Announcements & upcoming events



1st HUPO Glycoproteomics Initiative (HPP-HGI) Study

HUPOST, 29 May 2018


Update on the Human Glycoproteomics Initiative (HGI) 

HUPOST, 28 February 2019


Completion of the 1st HGI study 

HUPOST, 31 August 2021


Kawahara R et al., 2021 Nat Methods. Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data. Accepted for publication September 22, 2021

DOI: 10.1038/s41592-021-01309-x 

HUPO ReCONNECT 2021 “Hot Topic Discussion” session on “Glycoproteomics needs Glycobioinformatics”. Speakers and panellists are Morten Thaysen-Andersen (HGI), Robert Chalkley, Frederique Lisacek. Moderator is Rebekah Gundry. The session will be hosted virtually Thursday Nov 18, 23:00 - 00:00 UTC.

HUPO ReCONNECT 2021

“Closing Ceremony & Award Lectures” session

Award lecture on glycoproteomics technologies and interface to proteomics sciences by Nicolle H. Packer (HGI) who receives the Distinguished Achievement in Proteomic Sciences Award. 

Friday Nov 19, 07:35 (UTC) 


 

Future HGI studies

Follow-up efforts seeking to compare the performance of the most recent glycoproteomics software upgrades and informatics solutions not included in the 1st HGI study are being drafted within the next study of the Human Glycoproteomics Initiative. Studies addressing key challenges relating to glycopeptide data acquisition are also planned. Community-wide calls for participation in these studies will be made soon.





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