The Human Infectious Diseases HPP initiative (HID-HPP) is a world-wide coordinated enterprise to encourage and promote collaboration between scientists working on proteomics studies related to infectious diseases caused by virus, bacteria, fungi and parasites.

Infectious diseases constitute one of the leading causes of illness and death throughout the world, in particular in low income countries. Lower respiratory infections, HIV/AIDS and diarrheal diseases are ranked in the top ten causes of death globally, whereas malaria and tuberculosis are two of the major ten causes of death in low income countries. In developed countries infectious diseases are also important in immunosuppressed patients and transplant recipients. New diagnostic tests, therapeutic agents and vaccines are required to control these infectious diseases. International collaboration of scientists working in infectious diseases and proteomics is therefore essential to promote these researches.

Current lines of work:

• Development of SRM methods for detection and quantification of human and microbial proteins
• Detection and quantification of these proteins by affinity or antibodies based technologies
• Characterization of microbial-host protein interaction networks
• Identification of host factors as antimicrobial therapeutic targets
• Dissemination of HID-HPP activities (reports, special issues, etc.)

Websites and links:

Papers:

• A Perspective on Proteomics of Infectious Diseases. Venkatesh A, Gil C, Fuentes M, LaBaer J, Srivastava S. Proteomics Clin Appl. 2018;12(4):e1700139. doi: 10.1002/prca.201700139. PMID: 29282898 

• Self-assembling functional programmable protein array for studying protein-protein interactions in malaria parasites. Arévalo-Pinzón G, González-González M, Suárez CF, Curtidor H, Carabias-Sánchez J, Muro A, LaBaer J, Patarroyo MA, Fuentes M. Malar J. 2018; 17(1) : 270. doi:10.1186/s12936-018-2414-2 PMID 30016987

• Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription. Gilbertson S, Federspiel JD, Hartenian E, Cristea IM, Glaunsinger B. Elife. 2018 ; 7. doi:10.7554/eLife.37663 PMID 30281021

• Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Jean Beltran PM, Cook KC, Hashimoto Y, Galitzine C, Murray LA, Vitek O, Cristea IM. Cell Host Microbe. 2018 ; 24(4) : 526–541.e7. doi:10.1016/j.chom.2018.09.002 PMID 30269970

• Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Lum KK, Song B, Federspiel JD, Diner BA, Howard T, Cristea IM. Cell Syst. 2018 ; 7(6) : 627–642.e6. doi:10.1016/j.cels.2018.10.010 PMID 30471916

• Location is everything: protein translocations as a viral infection strategy. Cook KC, Cristea IM. Curr Opin Chem Biol. 2019 ; 48 : 34–43. doi:10.1016/j.cbpa.2018.09.021 PMID 30339987

• Orchestration of protein acetylation as a toggle for cellular defense and virus replication. Murray LA, Sheng X, Cristea IM.Nat Commun. 2018 ; 9(1) : 4967. doi:10.1038/s41467-018-07179-w PMID 30470744

• Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. Rowland EA, Snowden CK, Cristea IM. Curr Opin Chem Biol. 2018; 42:76-85. doi: 10.1016/j.cbpa.2017.11.003. PMID: 29169048

• Diagnosis of Invasive Candidiasis: From Gold Standard Methods to Promising Leading-edge Technologies. Pitarch A, Nombela C, Gil C. Curr Top Med Chem. 2018 ; 18(16) : 1375–92. doi:10.2174/1568026618666181025093146 PMID 30360714

• The development of a new parameter for tracking post-transcriptional regulation allows the detailed map of the Pseudomonas aeruginosa Crc regulon. Corona F, Reales-Calderón JA, Gil C, Martínez JL. Sci Rep. 2018 ; 8(1) : 16793. doi:10.1038/s41598-018-34741-9 PMID 30429516

• Identification of the Missing Protein Hyaluronan Synthase 1 in Human Mesenchymal Stem Cells Derived from Adipose Tissue or Umbilical Cord. Clemente LF, Hernáez ML, Ramos-Fernández A, Ligero G, Gil C, Corrales FJ, Marcilla M. J Proteome Res. 2018 Jul 6. doi: 10.1021/acs.jproteome.8b00384. PMID: 29974749

• Unraveling Gardnerella vaginalis Surface Proteins Using Cell Shaving Proteomics. Marín E, Haesaert A, Padilla L, Adán J, Hernáez ML, Monteoliva L, Gil C. Front Microbiol. 2018; 9:975. doi: 10.3389/fmicb.2018.00975. eCollection 2018. PMID: 29867878

• SILAC-based phosphoproteomics reveals new PP2A-Cdc55-regulated processes in budding yeast. Baro B, Játiva S, Calabria I, Vinaixa J, Bech-Serra JJ, de LaTorre C, Rodrigues J, Hernáez ML, Gil C, Barceló-Batllori S, Larsen MR, Queralt E. Gigascience. 2018; 7(5). doi: 10.1093/gigascience/giy047. PMID: 29688323

• The external face of Candida albicans: A proteomic view of the cell surface and the extracellular environment. Gil-Bona A, Amador-García A, Gil C, Monteoliva L. J Proteomics. 2018;180:70-79. doi: 10.1016/j.jprot.2017.12.002. Epub 2017 Dec 6. PMID:29223801

• In vivo Proteomics Approaches for the Analysis of Bacterial Adaptation Reactions in Host-Pathogen Settings. Pförtner H, Depke M, Surmann K, Schmidt F, Völker U. Methods Mol Biol. 2018;1841:207-228. doi: 10.1007/978-1-4939-8695-8_15. PMID: 30259489

• Analysis of Staphylococcus aureus proteins secreted inside infected human epithelial cells. Surmann K, Depke M, Dhople VM, Pané-Farré J, Hildebrandt P, Gumz J, Schaible UE, Völker U, Schmidt F. Int J Med Microbiol. 2018;308(6):664-674. doi: 10.1016/j.ijmm.2018.06.002. PMID: 29941384

• Secreted Immunomodulatory Proteins of Staphylococcus aureus Activate Platelets and Induce Platelet Aggregation. Binsker U, Palankar R, Wesche J, Kohler TP, Prucha J, Burchhardt G, Rohde M, Schmidt F, Bröker BM, Mamat U, Pané-Farré J, Graf A, Ebner P, Greinacher A, Hammerschmidt S. Thromb Haemost. 2018 Apr;118(4):745-757. doi: 10.1055/s-0038-1637735. PMID: 29554697

• Staphylococcus aureus controls interleukin-5 release in upper airway inflammation. Bachert C, Holtappels G, Merabishvili M, Meyer T, Murr A, Zhang N, Van Crombruggen K, Gevaert E, Völker U, Bröker BM, Vaneechoutte M, Schmidt F. J Proteomics. 2018;180:53-60. doi: 10.1016/j.jprot.2017.12.003. PMID: 29247803

• A Proteogenomic Analysis of Haptoglobin in Malaria. Awasthi G, Tyagi S, Kumar V, Patel SK, Rojh D, Sakrappanavar V, Kochar SK, Talukdar A, Samanta B, Das A, Srivastava S, Patankar S. Proteomics - Clin Appl. 2018 ; 12(4) : 1700077. doi:10.1002/prca.201700077 PMID 28960920

• A Perspective on Proteomics of Infectious Diseases. Venkatesh A, Gil C, Fuentes M, LaBaer J, Srivastava S. Proteomics Clin Appl. 2018;12(4):e1700139. doi: 10.1002/prca.201700139. PMID: 29282898

• Identification of Highly Expressed Plasmodium Vivax Proteins from Clinical Isolates Using Proteomics. Venkatesh A, Lahiri A, Reddy PJ, Shastri J, Bankar S, Patankar S, Srivastava S. Proteomics - Clin Appl. 2018 ; 12(4) : 1700046. doi:10.1002/prca.201700046 PMID 28841253

• Proteomics-based investigations of neglected and tropical diseases. Srivastava S. Proteomics - Clin Appl. 2018 ; 12(4) : 1800076. doi:10.1002/prca.201800076 PMID 25684126

• Developments in the Diagnostic Techniques of Infectious Diseases: Rural and Urban Prospective. Srivastava S, Singh PK, Vatsalya V, Karch RC. Adv Infect Dis. 2018;8(3):121-138. doi: 10.4236/aid.2018.83012. PMID: 30197838

• Clinical Proteomics and Cytokine Profiling for Dengue Fever Disease Severity Biomarkers. Jadhav M, Nayak M, Kumar S, Venkatesh A, Patel SK, Kumar V, Sharma S, Samanta B, Deb S, Karak A, Verma S, Talukdar A, Kochar SK, Mansukhani P, Gandhi M, Srivastava S. OMICS. 2017;21(11):665-677. doi: 10.1089/omi.2017.0135. PMID: 29091011

• Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes. Wilk L, Happonen L, Malmström J, Herwald H. J Proteome Res. 2018 ; 17(1) : 600–17. doi:10.1021/acs.jproteome.7b00701 PMID 29160079

• Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein. Persson ST, Hauri S, Malmström J, Herwald H. Cell Microbiol. 2018; 20(1) : e12792. doi:10.1111/cmi.12792 PMID 28973822

• Streptococcus pyogenes Infection and the Human Proteome with a Special Focus on the Immunoglobulin G-cleaving Enzyme IdeS. Karlsson CAQ, Järnum S, Winstedt L, Kjellman C, Björck L, Linder A, Malmström JA. Mol Cell Proteomics. 2018; 17(6) : 1097–111. doi:10.1074/mcp.RA117.000525 PMID 29511047

• The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking. Grant M, Kilsgård O, Åkerman S, Klinge B, Demmer RT, Malmström J, Jönsson D. J Innate Immun. 2018: 1–12. doi:10.1159/000494146 doi:10.1159/000494146 PMID 30485856

• Associating H2O2-and NO-related changes in the proteome of Mycobacterium smegmatis with enhanced survival in macrophage. Ganief N, Sjouerman J, Albeldas C, Nakedi KC, Hermann C, Calder B, Blackburn JM, Soares NC. Emerg Microbes Infect. 2018; 7(1) : 212. doi:10.1038/s41426-018-0210-2 30546046PMID 30546046

• Global proteome and phosphoproteome dynamics indicate novel mechanisms of vitamin C induced dormancy in Mycobacterium smegmatis. Albeldas C, Ganief N, Calder B, Nakedi KC, Garnett S, Nel AJM, Blackburn JM, Soares NC. J Proteomics. 2018 ; 180 : 1–10. doi:10.1016/j.jprot.2017.10.006 PMID 29038038

• Proteomic comparison of three clinical diarrhoeagenic drug-resistant Escherichia coli isolates grown on CHROMagarTMSTEC media. Kalule JB, Fortuin S, Calder B, Robberts L, Keddy KH, Nel AJM, Garnett S, Nicol M, Warner DF, Soares NC, Blackburn JM. J Proteomics. 2018 ; 180 : 25–35. doi:10.1016/j.jprot.2017.09.003 PMID 28887208

• Self-assembling functional programmable protein array for studying protein-protein interactions in malaria parasites. Arévalo-Pinzón G, González-González M, Suárez CF, Curtidor H, Carabias-Sánchez J, Muro A, LaBaer J, Patarroyo MA, Fuentes M. Malar J. 2018; 17(1) : 270. doi:10.1186/s12936-018-2414-2 PMID 30016987

• Proteomics to study macrophage response to viral infection. Nyman TA, Matikainen S. J Proteomics. 2018 ; 180 : 99–107. doi:10.1016/j.jprot.2017.06.018 PMID 28647517

• Secretome profiling of Propionibacterium freudenreichii reveals highly variable responses even among the closely related strains. Frohnmeyer E, Deptula P, Nyman TA, Laine PKS, Vihinen H, Paulin L, Auvinen P, Jokitalo E, Piironen V, Varmanen P, Savijoki K. Microb Biotechnol. 2018 ; 11(3) : 510–26. doi:10.1111/1751-7915.13254 PMID 29488359

• Published special issue on “Trends in Microbial Proteomics” in Journal Proteomics (2014).
• Published special issue on “Virology meets Proteomics” in Proteomics journal (2015).
• Published special issue on “Proteomics in Infectious Disease” in Molecular and Cellular Proteomics journal (2017)
  
• Special issue on “Proteomics in Infectious Diseases” in Journal of Proteomics (deadline for submission is 15 December 2016)

Leadership:

For more information or participation opportunities please contact office(at)hupo.org.