The 10th HUPO HPP Special Issue has been published in the April issue of the Journal of Proteome Research (https://pubs.acs.org/toc/jprobs/22/4). As a consequence of lab shut downs in the pandemic, a smaller and later Special Issue was necessary. The hallmark anchor paper of every Special Issue is the HPP Metrics paper, lead by Dr Gil Omenn and the leaders of neXTprot, the Peptide Atlas, the HPP, C-HPP and B/D-HPP: “The 2022 Report on the Human Proteome from the HUPO Human Proteome Project” by Gilbert S. Omenn, Lydie Lane, Christopher M. Overall, Charles Pineau, Nicolle H. Packer, Ileana M. Cristea, Cecilia Lindskog, Susan T. Weintraub, Sandra Orchard, Michael H. A. Roehrl, Edouard Nice, Siqi Liu, Nuno Bandeira, Yu-Ju Chen, Tiannan Guo, Ruedi Aebersold, Robert L. Moritz, and Eric W. Deutsch (https://pubs.acs.org/doi/10.1021/acs.jproteome.2c00498)
ABSTRACT: The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, “A Function for Each Protein”.
For 2024, the format of the 11th HUPO HPP Special Issue will differ. Papers focused on the HPP, the neXt-MP50, the neXt-CP50, and the Grand Challenge will be published in regular JPR issues after acceptance during this year. In December 2023 a HUPO HPP Virtual Issue will be compiled of these HPP papers and related articles published over the year.
For reports on missing protein discovery, authors must use the 2023-04-18 release of neXtProt and the checklist for the credible identification of missing proteins (https://www.nextprot.org/news/new-release-with-updated-proteomics-data).
An example of the HPP Virtual Issue is now online HUPO Human Proteome Project Virtual Special Issue, Associate Editor, Dr Chris Overall. This collection includes papers published this past year as part of the 10th HUPO HPP Special Issue, now online, along with highly cited papers from HUPO HPP SI’s of years past.
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