DATE: Wednesday, February 21, 2024
TIME: 7am PST / 10am EST / 4pm CET
LOCATION: Zoom (link to follow upon registration)
SPEAKER: Oliver Raether
WEBINAR DESCRIPTION:
Trapped ion mobility spectrometry (TIMS) is a powerful analytical technique that separates and characterizes gas-phase ions based on their mobility in a buffer gas. TIMS has been widely applied in various fields, such as proteomics, metabolomics, lipidomics, and pharmaceutical research. It offers sensitivity, speed, and resolution for complex and challenging samples.
LEARNING OBJECTIVES:
In the first part of this webinar, you will learn about the history of the TIMS research and development, including the chronological launch of the different timsTOF instruments and SW capabilities by Bruker. You’ll learn about the differences and similarities of the timsTOF instruments, the possible upgrade paths and software options.
In the webinar, you will also learn about the different data-independent acquisition (DIA) mass spectrometry methods currently used in proteomics and how new approaches benefit from the additional ion mobility dimension and new acquisition modes.
Finally, in the third part of this webinar, you will learn about some of the future approaches that are currently under development for the TIMS technique, such as TIMS gas phase fractionation and filtering. This is a novel setup that uses two or three TIMS analyzers in a row to separate and isolate different regions of the m/z vs 1/K0 space. This can increase the selectivity and sensitivity of the TIMS technique, and improve applications and workflows especially for heterogeneous proteomics samples. You will see how these methods work, and what are the advantages and challenges of implementing it.
SPEAKER BIO:
Oliver Raether is Research and Development Manager at Bruker Daltonics in Bremen. He received his M.Sc. in engineering from the Hamburg University of Technology (1995). Over the past nearly three decades he and his colleagues have developed orthogonal time of flight mass spectrometers including since 2010 the timsTOF product line. He has produced 14 peer reviewed journal articles and is inventor/co-inventor of 71 patents in the field of mass spectrometry and, more recently, ion mobility spectrometry (h-index 13). His awards include the HUPO Science and Technology Award for contributions on Trapped Ion Mobility Mass Spectrometry Instrumentation (2020).
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