The 33rd HBPP Workshop took place from May 22nd to 24th 2024, in Naas, just outside Dublin, in Ireland. It was a very successful, small but intense meeting with participants from Australia, Brazil, Germany, Ireland, Saudi Arabia, Sweden, United Kingdom, and the USA.
The meeting addressed clinical, animal, and cellular findings for neurodegeneration (e.g. Alzheimer’s disease, Parkinson’s disease, Multiple Sclerosis) and neuropsychiatric conditions such as Schizophrenia, Bipolar disorder and Autism. Whilst most of the work presented employed mass spectrometry-based proteomics, there was a trend of employing large-scale protein arrays of different kinds as well as combination of proteomics with other –omics platforms. Advanced statistical analyses including multivariate machine learning as well as Mendelian randomization of GWAS findings were elegantly combined with proteomics findings. Pathway analyses and investigations of posttranslational modifications were also presented.
Christopher Whelan from Johnson and Johnson presented an update from the findings of the open-access proteomics resource profiling on blood plasma samples collected from over 50,000 UK Biobank participants to elucidate the biological mechanisms underlying proteo-genomic discoveries (Nature. 2023 Oct;622(7982):329-338. doi: 10.1038/s41586-023-06592-6. Epub 2023 Oct 4.PMID: 37794186.).
In addition, we welcomed PreOmics at the meeting to display their latest products. We also discussed lab sustainability actions and accreditation (My Green Lab).
There was ample time for networking at the meeting, and it was exciting to hear about related lab exchanges that are ongoing and planned.
The discussions and continuing work done by HBPP is significant and helps to advance the development and roll out of neuroproteomic methods to acquire holistic insights of the brain proteome in health and disease.
The 34th HUPO HBPP workshop will take place in Toledo, USA, in 2025. Further details will be announced on the HBPP website https://hupo.org/Brain and https://x.com/BrainProteomics in due course.
For more information regarding this workshop or the Human Brain Proteome Project, please visit the HUPO website here and/or contact: Melanie Föcking (mfocking@rcsi.ie, current chair of HBPP) or Darragh O’Brien (darragh.obrien@ndm.ox.ac.uk, HBPP communications officer).
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