During the years, the scientists from the entire world, especially the ones involved in the Human Proteome Project (HPP) have accumulated massive knowledge on human proteins. Since 2012, the advance of the Chromosome-centric HPP (C-HPP) defined stringent criteria of protein existence. All of this information was collected in the neXtProt database. It became a valuable resource of human protein research. In 2023, a mirror site of neXtProt was established by Chi-Biotech in Shenzhen, China, facilitating the access from Asian countries.
In 2024, the neXtProt database was discontinued. Therefore, a new HUPO-branded knowledgebase, named HPP Portal, is under construction by the team of Dr. Gong Zhang (Jinan University, China) and Chi-Biotech.
The HPP Portal aimed to continue the idea of neXtProt, cataloging the knowledges to each human protein. It contains the information to UniProt, Human Protein Atlas, etc., and includes the Protein Evidence (PE) levels. A notable change is that the annotation is now based on GENCODE. This facilitates the connection to the genome and transcriptome data, and reduces the inconsistency when processing multiomics datasets. In addition, Function Evidence (FE) levels of each protein is provided, summarizing the current knowledge on protein functions. For those proteins without known functions, the predicted functions will be also included. The HPP Portal, fully HUPO and HPP branded, is the knowledge hub supporting the HPP Grand Challenge.
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