Henning Hermjakob, European Bioinformatics Institute, UK
Biomolecular pathways are a key tool to put proteomics results into context, and pathway databases are often the first port of call to make sense of long lists of identifications and quantitations. Reactome (https://reactome.org) [1] is an open source, open data knowledge base of curated human pathways. While Reactome employs full time curators, we depend critically on voluntary domain experts who provide their time and knowledge to ensure quality and coverage of the pathways annotated in the database. Similar to manuscript reviewers, these essential community contributors are hard to attract, and the Reactome team would like to reach out to the HUPO community to contribute to the extension and validation of Reactome content. Recently, we have added features that allow to search for contributors by name, and for them to claim their contributions to their ORCID (https://orcid.org/) profile with a few clicks [2], contributing to efforts to provide credit for open data.
So, if you have a favorite pathway, please check if it’s already perfect in Reactome, and if not, click on https://reactome.org/community/collaboration to provide your expertise, and to support your future pathway analysis!
When you give presentations please disseminate this important message- using the slides included here.
Example of a Reactome pathway overview diagram (free to download as vector graphic).
1: Jassal B, et al. The reactome pathway knowledgebase. Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503. doi: 10.1093/nar/gkz1031. PubMed PMID: 31691815.
2: Viteri G, et al. Reactome and ORCID-fine-grained credit attribution for community curation. Database (Oxford). 2019 Jan 1;2019. pii: baz123. Doi: 10.1093/database/baz123. PubMed PMID: 31802127.
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