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The PSI meeting 2024 will take place from March 18-20th 2024 at the Kyoto University, Japan.

View event details here.

The meeting is sponsored by: JPOST (JST-NBDC) and JPDM (JSPS).

Organizers: Yasushi Ishihama & Shujiro Okuda.

Program:  The provisional agenda will be posted soon.

Registration:  Registration for attending the meeting is now open.

The January HUPOST is now available.....check out the latest HUPO 2024 news, ETC Webinars, ECR Manuscript Competition, upcoming events & much more...

The HUPO Early Career Researcher (ECR) Initiative is delighted to welcome Nick Riley and Mahshid Moballegh Nasery.

Nick Riley is an assistant professor of chemistry at the University of Washington. With a background in mass spectrometry instrumentation, proteomics, and glycobiology from his graduatework with Prof. Josh Coon at University of Wisconsin-Madison and his postdoctoral work with Prof. Carolyn Bertozzi at Stanford University, he now leads a research program focused on innovative bioanalytical and chemical biology technologies to investigate essential principles of glycocode regulation and dysregulation. Nick has been involved with HUPO and US HUPO for a number of years and is excited to join the HUPO ECR committee to support the vibrant and supportive communities that help early career scientists build their scientific careers in proteomics research.

Mahshid Moballegh Nasery pursued a diverse academic journey, beginning with a Bachelor's in Chemistry and delving closer into biology with a Master's in Medical Toxicology, where her focus on cancer led to publications in articles and a chapter book. Her passion for proteomics started to grow as she attended her proteomics course and attended an ECR day meeting! Currently engaged in research at the University of Debrecen, under the supervision of Dr. Eva Csosz. Her recent membership in YPIC (Young Proteomics Investigators Club) reflects her eagerness to expand her network and engage actively with fellow proteomics scientists. She aims to deepen her involvement in various activities, leveraging her multi-disciplinary background, to contribute meaningfully to the scientific community. Driven by a thirst for knowledge and a desire to make impactful contributions, Mahshid is passionate about exploring within the vibrant realm of proteomics and biochemistry.

What is your current position and affiliation?
I am a project group leader (a position somewhat between postdoc and group leader) at the Max Planck Institute of Biochemistry within the group of Matthias Mann.

How would you like your work to contribute to the field of proteomics?
I currently focus on clinical mass spectrometry-based proteomics and nearly any project I am working on involves patient samples or is a direct collaboration with clinicians. I would like to continue employing this powerful method to uncover biological mechanisms and better understand diseases, which ultimately will benefit patients with better treatments. In the best case scenario, this leads for example to the discovery of novel biomarkers or therapeutic targets, but also a better functional understanding without the identification of distinct single biomarkers is a step in the right direction. Biomarker discovery is often done with large patient cohorts and I hope to contribute to the field by enabling such studies from a technical perspective and providing the community with unique datasets. In parallel to this work, I would like to transform proteomics from a method for biomarker discovery by retrospective analysis to a tool for pro- and diagnostics in the future.

What have you found in the HUPO community/congress?
I had the chance to attend the HUPO world congresses two times so far. I found it to be a perfect intersection of different interest groups forming a thriving community between biological expertise and technical solutions.

How was your experience/what did it mean to present your work at HUPO?
Having been invited to the ECR manuscript competition to HUPO in Busan to present my work meant a lot to me. Sharing the excitement about new findings is definitely a driver of motivation for me to work as a scientist and being given the opportunity to do so in such a venue has been a major pleasure. I received a plethora of positive feedback from this wonderful community, which is truly motivating.

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WEBINAR DESCRIPTION:

RPPA is a high-throughput protein array technology that simultaneously measures hundreds or thousands of samples on glass slides with high precision and reliability, using specific antibodies. RPPA and mass spectrometry-based protein profiling are complementary technologies for protein profiling. In attending this webinar, attendees will learn about RPPA's high-throughput capabilities and laser-captured microdissection technology. They will understand how these technologies precisely measure protein expression, modifications, and phosphorylation in tumor cells.

SPEAKER BIO:

Dr. Rosa Isela Gallagher obtained her Ph.D. in Cell and Molecular Biology from GMU in 2019. She has accumulated more than 15 years of expertise in Reverse Phase Protein Array (RPPA) and Laser Capture Microdissection (LCM) technologies and is currently a Senior Research Scientist in the Center for Applied Proteomics and Molecular Medicine, led by Drs. Lance Liotta and Emanuel Petricoin III, the inventors of both technologies. RPPA is a high-throughput, antibody-based protein array technology capable of conducting assays on small amount of materials on thousands of samples simultaneously. This platform measures protein expression levels and modifications, including phosphorylation. Dr. Gallagher’s current research focuses on the molecular profiling of tumor cells utilizing LCM and RPPA to investigate unique signaling pathway profiles and new disease mechanisms to guide diagnosis, prognosis, and targeted therapeutics.

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The December HUPOST is now available.....check out the ETC webinars, HPP Chair & Co-chair nominations, C-HPP updates, upcoming events & a farewell message from HUPOST editor Ben Garcia...

DATE: Wednesday, February 21, 2024
TIME: 7am PST / 10am EST / 4pm CET
LOCATION:  Zoom (link to follow upon registration)
SPEAKER:  Oliver Raether

SPEAKER BIO:

Oliver Raether is Research and Development Manager at Bruker Daltonics in Bremen. He received his M.Sc. in engineering from the Hamburg University of Technology (1995). Over the past nearly three decades he and his colleagues have developed orthogonal time of flight mass spectrometers including since 2010 the timsTOF product line. He has produced 14 peer reviewed journal articles and is inventor/co-inventor of 71 patents in the field of mass spectrometry and, more recently, ion mobility spectrometry (h-index 13). His awards include the HUPO Science and Technology Award for contributions on Trapped Ion Mobility Mass Spectrometry Instrumentation (2020).

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DATE: Wednesday, January 24, 2024
TIME: 6am PST / 9am EST / 3pm CET
LOCATION:  Zoom (link to follow upon registration)
SPEAKER: Daniel DeBord, PhD

WEBINAR DESCRIPTION:

Protein identification is of fundamental importance in many areas of proteomics. Its applications include determining the presence or absence of an expected protein in a sample of interest, identifying an unknown protein present in a biological sample, and identifying a protein responsible for biochemical activity in an isolated protein fraction. In some cases, mass spectrometry or affinity-based methods may be suitable options, but these methods can face substantial challenges. Scientists need the ability to identify and measure peptide modifications, structures, and impurities more definitively and faster. Driven by structures for lossless ion manipulation (SLIM) technology, the MOBIE® instrument’s high-resolution ion mobility mass spectrometry platform separates and identifies the most challenging molecules with unprecedented resolution without compromising speed. By combining the MOBIE® platform’s high-resolution ion mobility mass spectrometry (HRIM-MS) data with liquid chromatography, more accurate separation and identification of impurities and posttranslational modifications (PTMs) can be achieved, reducing run times and costs.

LEARNING OBJECTIVES:

1. Attendees will learn Attendees will learn about (1) separation science, including SLIM (structures for lossless ion manipulation) and high-resolution ion mobility (HRIM); (2) the trade-off between speed, resolution, and reproducibility; and (3) accuracy for targeted lipidomics, peptide characterization, glycan analysis, PFAS, and many other workflows.
2. Why Attend?  AAttendees will uncover insights into how to incorporate HRIM into traditional analytical workflows and where the technology is used to answer clinical questions.

SPEAKER BIO: 

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The Human Proteome Project (HPP) was launched in 2010 under the aegis of HUPO. The vision of HUPO is that HPP activities will collectively and ultimately lead to breakthroughs enabled by proteomics, in medicine, biotechnology and the life sciences, thereby leaving a legacy of human proteome research. 

The HPP continues to make progress, addressing three major components, Chromosome-HPP (C-HPP), Biology and Disease-HPP (BD-HPP) and the HPP-Grand Challenge. It is focused on:

1. Cataloguing the human protein ‘parts’ list with high accuracy.
2. Understanding the complexity and function of the human proteome (including post-translational modifications, splice variants, proteoforms, small proteins/peptides, etc.).
3. Document and provide data deposition and analysis globally through portals (e.g., ProteomeXchange) and via major specific efforts (e.g., Human Protein Atlas, PeptideAtlas, neXtProt) with communal guidelines/metrics published with an annual communal reanalysis of whole human proteome’s protein existence (PE) status and making proteomics an integrated complement across the clinical, biomedical and life sciences research space.
4. In 2021, the HPP inaugurated the establishment of the HPP Grand Challenge project “A function for every protein”. 

ROLES / RESPONSIBILITIES:

Chair

The HPP Chair leads the development and implementation of the Human Proteome activities of the C-HPP, the B/D-HPP and the HPP Grand Challenge. The term of the HPP Chair is two years and so the position becomes vacant on December 31, 2024. To ensure a smooth and consistent transition, the incoming Chair will sit on the HPP EC for one year (2024) prior to their 2-year term (2025-2026) and also be present as past Chair in 2027.

Co-chair

The HPP Co-Chair helps lead the development and implementation of the Human Proteome activities of the C-HPP, the B/D-HPP and the HPP Grand Challenge with the HPP Chair. The term of the HPP Co-Chair is two years and is staggered with appointment of the HPP Chair. The HPP Co-Chair position becomes vacant on December 31, 2023, for a 2-year term (2024-2025).

Responsibilities:

• Chair the HPP Executive Committee and work with the HPP strategic advisory group to maximize the impact of HPP
• Evolve and implement the strategic goals of the HPP by working with the HPP Executive Council and its membership to accelerate progress, assess the goals and performance of each component, and connect the components of the HPP
• Supporting all HPP initiatives (C-HPP, B/D-HPP) and the HPP Grand Challenge
• Represent the HPP on the HUPO Executive Committee monthly calls
• Represent the HPP at national/international/strategic meetings, as needed
• Liaison with other HUPO Committees (e.g., HUPO Marketing and HUPO Early Career Committee) and initiatives (e.g., Antibody and Single Cell) to support the development of science and education
• Work with HUPO External Development Committee (HEDI) and the HUPO EC to work on strategic projects and funding with other resources for the scientific community

QUALIFICATIONS

HUPO is currently seeking scientifically strong, strategic, vibrant, enthusiastic and collegial leaders who will be suitable candidates to lead, build, advance, and represent the HPP. HUPO is keen to ensure regional and gender equity across its management structures. This position is honorary and in line with the many organizational positions within the HUPO Executive Committee.

APPLICATIONS

All candidates must be active HUPO members and scientists from the public or private sector with professional experience in the educational, research, or commercial activities related to the HPP. Applications will be accepted and a vote conducted. The successful candidate will be reviewed and approved by the HUPO Executive Committee.

To apply, please submit:

1. Your CV
2. A recent photo (in JPEG high-resolution format)
3. A statement of the position in which you are applying
4. A one-page vision statement outlining why you are a suitable candidate for the position.

SUBMISSIONS

To: office@hupo.org

Deadline: December 15, 2023

QUESTIONS

Email Charles Pineau (current HPP Chair) charles.pineau@inserm.fr