Jochen Schwenk (Chair), Sweden
The HPPP was initiated in 2002 as the means to overcome the major challenges (e.g. sensitivity and analytical depth) for proteomics studies utilising blood plasma. The HPPP provided the strategy to deal with the growing numbers of plasma samples being systematically collected, stored, and accessible through biobanks.
Overall aim: To collect and facilitate the advances in plasma protein analysis using different technologies, diseases, and concepts.
The HPPP serves to bring together different contributions to plasma proteomics from the perspective of mass spectrometry and affinity-based assays and provide a platform to discuss success stories, technological possibilities, viewpoints and perspectives on how plasma proteomics has and will continue to advance.
In a study lead by Jochen Schwenk and Eric Deutsch, 3,509 plasma proteins determined by mass spectrometry have been reported. The data are accessible through PeptideAtlas. The study also provides a historical view on the HPPP project and discusses the portfolio of targeted MS analysis, available multiplexed affinity assays, as well as considerations concerning sample handling and study design for plasma proteomics.
Activities for 2019:
Besides the publications shown below, HPPP has started to monitor recent publications to shortlist some of these in open access Zotero list of plasma proteomics papers. The aim is to keep this list updated, so we appreciate suggestions about published work that might be missing.
Collection of Recent Papers:
Related and useful links:
HPPP Data Central, hosted by PeptideAtlas.