News

Maggie Lam, University of Colorado, USA

If you have not had the chance to read them, I would like to draw your attention to a number of excellent HUPOST articles contributed by members of our community:

• Yuanwei Xu and Hui Zhang from Johns Hopkins University wrote about glycosylation, an important post-translational modification that is also notoriously challenging to analyze. The article provides a useful catalog of mass spectrometry and computational tools that are helping scientists identify the sites and glycans involved in the glycosylation of the human proteome. [link: https://hupo.org/HPP-News/9137783]
• Sri Ramarathinam and Anthony Purcell from Monash University introduced the importance and challenges of surveying the landscape of HLA-peptide ligands in the immune systems. Using mass spectrometry, "immunopeptidomics" approaches are becoming a powerful tool to assess the target repertoire of immune surveillance in the body. [link: https://hupo.org/HPP-News/9068648]
• In their article in the June issue, Mohamed Elzerk and Kathryn Lilley from the University of Cambridge wrote a very informative mini-review on using mass spectrometry and machine learning methods to tag the spatial localization of proteins inside the cell, and the ways proteomics tools are helping advance understanding into membrane trafficking in the cell. [link: https://www.hupo.org/HUPOST/8999407]
• Last but not least, an eminently relevant article given the ongoing global pandemic from SARS-CoV-2 infections, Cora Betsinger and Ileana Cristea from Princeton University walked us through the many ways where knowledge of the human proteome is helping researchers combat emerging viral pathogens, from understanding the structure and components of infectious virus particles to identifying diagnostic and prognostic markers in patient serum samples. [link: https://hupo.org/HPP-News/8940074]

We are actively looking for more articles about various developments and applications in proteomics in the coming months on the HUPOST column. We are especially interested in articles coauthored by early career investigators with their mentors in any proteomics or related fields. So please feel free to reach out to us if you would like to contribute a HUPOST article. We think this is a fantastic way to showcase your research, write about recent developments that excite you and issues you care about, and share it with the HUPO community.

Lastly, we are excited to be preparing a number of outreach activities for HUPO B/D-HPP in the coming months, including social media outreach via Twitter and webinars. Please contact me via maggie.lam@cuanschutz.edu if you are interested in participating.