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7th C-HPP Newsletter Highlights

29 May 2018 4:19 PM | Anonymous member (Administrator)

Péter Horvatovich, University of Groningen, Netherlands

On May 1, 2018, the C-HPP Consortium released the 7th C-HPP Newsletter summarizing 2017 C-HPP activities. Selected highlights from this C-HPP Newsletter are:

  • Reporting two C-HPP PIC decisions with respect to future directions of C-HPP consortiums made in HUPO 2017, Dublin: (1) an extension of C-HPP period to 2027: This action was necessary for completion of the human proteome mapping and identification of at least three post-translational modifications of each human protein (2) launch of neXt-CP50 challenge: This aims to discover function(s) of 50 PE1 proteins of unknown functions termed uPE1 by chromosome-centric approach in three years (list of uPE1 is available in neXtProt using SPARQL query NXQ_00022).
  • Prospective article of Ekaterina Poverennaya and Andrey Lisitsa from Orekhovich Institute of Biomedical Chemistry (Moscow, Russia, Chromosome 18 team) on the use of various gene editing technologies to found function(s) of uPE1 proteins in cell lines.
  • Lydie Lane from SIB provides a summary on the new neXtProt release (2018-1-17). Noted were an increase of PE1 human protein from 17008 to 17470 compared to the previous release (2017-1-17) and list new features of neXtProt such as viewing SRM peptides of human proteins and new SPARQL queries to list high proline content proteins (NXQ_00225). In particular, one can see the list of proteins detected in blood plasma, urine, or cerebrospinal fluid, which aims to support biomarkers research. For the detection claim of missing proteins, it usually requires at least two uniquely mapping peptides with length larger than 9 amino acids (NXQ_00226). However, in identifying proteins with experimentally determined long alpha helices (defined as a length longer than 75 amino acids), the new release provides an example query of proteins having a specific secondary structure (NXQ_00230).
  • HUPO Award for “Discovery in Proteomic Sciences” was given to Chris Overall for his career-long achievements to discover new chemical labeling approaches to study N- and C- termini of proteins such as TAILS, PICS and ATOMS which have been highly useful for studying protease substrates and cleavage sites and establishing new research field of degradomics.
  • Highlights form 17th C-HPP Workshop in Tehran (April 27-28, 2017, Iran) and 18th C-HPP Workshop in Dublin (September 17 and 21, 2017, Ireland) summarizing C-HPP progress, achievements and discussion on future directions.
  • Updated scientific program of upcoming 19th C-HPP Workshop which will be held in Santiago de Compostela (June 16-17, 2018, Spain) in conjunction with 2018 EuPA Congress. 

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